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Arab Orthopaedic Board MCQs - Part 3

27 Apr 2026 105 min read 79 Views
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Learn more about Arab Orthopaedic Board MCQs - Part 3 and how to manage it. Practice Arab Orthopaedic Board MCQs Part 3. Review orthopedic surgery questions 101 to 150 for your board exam preparation.

Arab Orthopaedic Board MCQs - Part 3

Comprehensive 100-Question Exam


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Question 1

A 45-year-old male is brought to the trauma bay after an MVA. He is hypotensive (BP 70/40 mmHg) and tachycardic (HR 130 bpm). Primary survey reveals an unstable pelvis (APC III pattern). A pelvic binder is applied, and he receives 2 units of packed RBCs. His BP improves transiently but drops again to 75/45 mmHg. A FAST scan is negative. What is the most appropriate next step in management?





Explanation

In a hemodynamically unstable patient with a pelvic ring injury who remains hypotensive despite initial resuscitation and mechanical stabilization (pelvic binder), and who has a negative FAST (ruling out massive intra-abdominal hemorrhage), the next step is addressing pelvic bleeding. This is achieved via preperitoneal pelvic packing or pelvic angiography/embolization, depending on institutional protocols and available resources.

Question 2

A 55-year-old female presents with progressive groin pain 4 years after undergoing a metal-on-metal total hip arthroplasty. Inflammatory markers are normal, and radiographs show no loosening. A MARS MRI reveals a solid-cystic pseudotumor in the periprosthetic soft tissues. Serum cobalt and chromium levels are elevated. What histological finding is most characteristic of this condition?





Explanation

Adverse Local Tissue Reaction (ALTR) or ALVAL (Aseptic Lymphocytic Vasculitis-Associated Lesion) is characteristic of metal-on-metal hypersensitivity. Histology typically demonstrates a diffuse perivascular infiltrate of T-lymphocytes, high endothelial venules, and soft tissue necrosis. Neutrophils suggest acute infection, whereas non-caseating granulomas suggest sarcoid or mycobacterial infection.

Question 3

A 72-year-old male with a history of cervical spondylosis presents after a hyperextension injury to his neck from a low-level fall. He exhibits pronounced weakness in his upper extremities (deltoid and biceps 3/5, hand intrinsic 2/5) but retains 4/5 strength in his lower extremities. He has patchy sensory loss in his arms and hyperreflexia in his legs. MRI confirms spinal cord signal change at C4-C5 with severe preexisting stenosis. What is the most accurate statement regarding his condition?





Explanation

The patient has Central Cord Syndrome, which classically presents with disproportionate upper extremity weakness compared to the lower extremities. The classic anatomical explanation is the somatotopic organization of the lateral corticospinal tract, where the cervical (upper extremity) motor tracts are located more medially, closer to the central gray matter, making them more susceptible to central cord injury. The prognosis for full recovery of hand dexterity is generally poor.

Question 4

A 5-week-old female infant is treated with a Pavlik harness for developmental dysplasia of the hip (DDH) of the left side (Graf Type IV). After 4 weeks of compliant harness wear, an ultrasound demonstrates that the left hip remains completely dislocated. What is the most appropriate next step in management?





Explanation

If a Pavlik harness fails to achieve reduction after 3 to 4 weeks of compliant use in a young infant, it must be abandoned to prevent 'Pavlik harness disease' (damage to the posterior acetabular wall from the harness pushing the hip posteriorly). The next recommended step is typically a trial of a rigid abduction orthosis. If that fails, closed reduction and spica casting under anesthesia is indicated.

Question 5

A 24-year-old male presents with persistent wrist pain 8 months after a fall. Imaging reveals a proximal pole scaphoid nonunion. MRI demonstrates avascular necrosis (AVN) of the proximal pole, with the absence of punctate bleeding confirmed intraoperatively. Which of the following is the most appropriate surgical treatment?





Explanation

For a scaphoid proximal pole nonunion with established AVN (especially with absence of intraoperative punctate bleeding) and fragmentation or structural collapse, a free vascularized bone graft (such as from the medial femoral condyle) provides superior union rates compared to non-vascularized grafts or local pedicled grafts (like 1,2-ICSRA), which have higher failure rates in the setting of severe AVN.

Question 6

A 9-year-old Tanner stage I boy sustains a midsubstance anterior cruciate ligament (ACL) tear. He complains of recurrent instability despite 3 months of aggressive physical therapy. You recommend surgical reconstruction. Which of the following techniques minimizes the risk of physeal growth arrest in this patient?





Explanation

In prepubescent children with significant remaining growth (Tanner stage I or II, wide-open physes), physeal-sparing techniques are recommended to avoid growth arrest, leg length discrepancy, and angular deformities. These include the all-epiphyseal technique or extra-articular procedures like the modified MacIntosh (over-the-top IT band). Transphyseal techniques are typically reserved for older adolescents nearing skeletal maturity.

Question 7

A 15-year-old boy presents with knee pain. Radiographs show a mixed lytic and sclerotic lesion in the distal femur with a 'sunburst' periosteal reaction. A core needle biopsy confirms conventional high-grade osteosarcoma. Which MRI sequence is most accurate for determining the precise longitudinal intramedullary extent (skip lesions) of the tumor for surgical planning?





Explanation

T1-weighted longitudinal (sagittal or coronal) sequences of the entire involved bone are the most accurate imaging modality for evaluating the intramedullary extent of osteosarcoma and identifying skip metastases. The normal high-signal fatty marrow provides excellent contrast against the low-signal tumor tissue on T1 sequences.

Question 8

A 55-year-old poorly controlled diabetic male presents with a red, hot, swollen right foot. He denies any penetrating trauma or fever. Radiographs reveal periarticular fragmentation, subluxation at the tarsometatarsal joints, and debris, but no osteomyelitis. Laboratory markers (WBC, CRP) are normal to minimally elevated. According to the Eichenholtz classification, what is his current stage and the most appropriate initial treatment?





Explanation

The patient is in Eichenholtz Stage 1 (Fragmentation/Development stage), characterized by a red, hot, swollen foot, joint laxity, subluxation, and bony fragmentation on radiographs. The mainstay of initial treatment is immediate immobilization and offloading. The gold standard is a total contact cast (TCC) to prevent further deformity until the acute inflammatory phase resolves and the foot enters Stage 2 (Coalescence).

Question 9

You are treating a 30-year-old male with a lateral Hoffa fracture (coronal shear fracture of the lateral femoral condyle). You plan for open reduction and internal fixation. To achieve the most biomechanically stable construct for interfragmentary compression, what is the optimal trajectory for the screws?





Explanation

Biomechanical studies show that for a lateral Hoffa fracture, screws directed from posterior-to-anterior (PA) provide superior fixation strength, higher load-to-failure, and better compression compared to anterior-to-posterior (AP) screws. This is due to the thicker cortical bone posteriorly and the trajectory being perpendicular to the fracture plane.

Question 10

Bone morphogenetic proteins (BMPs) play a crucial role in osteoblast differentiation and bone formation. Which of the following best describes the intracellular signaling pathway activated immediately upon BMP-2 binding to its serine/threonine kinase cell surface receptor?





Explanation

BMPs bind to dimeric transmembrane serine/threonine kinase receptors. This binding causes phosphorylation and activation of receptor-regulated Smads (R-Smads), specifically Smad 1, 5, and 8. These then form a complex with the co-Smad (Smad 4), which translocates into the nucleus to regulate the transcription of osteogenic target genes like Runx2.

Question 11

A 12-year-old obese boy is diagnosed with a stable slipped capital femoral epiphysis (SCFE) of the left hip. During surgical counseling, the parents ask about the risk to the contralateral (right) hip. Prophylactic pinning of the contralateral hip is most strongly indicated if the patient has which of the following underlying conditions?





Explanation

Endocrine disorders (such as hypothyroidism, panhypopituitarism, and renal osteodystrophy) significantly increase the risk of developing bilateral SCFE (approaching 100% in some endocrine subgroups compared to ~20-30% in idiopathic cases). Therefore, prophylactic pinning of the contralateral asymptomatic hip is strongly recommended in patients with an underlying endocrine or metabolic disorder.

Question 12

Following a zone II flexor tendon repair, an early active mobilization protocol is planned to prevent adhesions. To safely withstand the forces of early active motion without gap formation or rupture, what is the minimum number of core suture strands crossing the repair site recommended?





Explanation

A 2-strand repair is generally considered too weak for early active motion protocols. A minimum of a 4-strand core repair (along with a robust epitendinous suture) is required to safely withstand the forces generated during early active mobilization and minimize the risk of gap formation and rupture. 6 or 8 strands provide even more strength but can increase bulk and affect tendon gliding.

Question 13

During a total knee arthroplasty for a valgus knee, trial implants are placed. The knee is balanced in flexion but remains significantly tight on the lateral side in full extension. Which of the following structures is the primary tether and should be released to address this specific asymmetry?





Explanation

In the valgus knee, the iliotibial band (ITB) acts as a primary lateral tether in extension. If the knee is tight laterally in extension but balanced in flexion, the ITB should be released or lengthened (e.g., via pie-crusting). The popliteus is a primary lateral stabilizer in flexion; releasing it would affect the flexion gap more than the extension gap.

Question 14

A 65-year-old female presents with neurogenic claudication and lower back pain. Imaging shows an L4-L5 grade I degenerative spondylolisthesis. Flexion-extension radiographs reveal 4 mm of dynamic translation. She fails 6 months of conservative management. According to the SPORT trial and current guidelines, what is the recommended surgical management?





Explanation

For patients with degenerative spondylolisthesis and spinal stenosis who fail conservative management, decompression (laminectomy) combined with instrumented posterolateral fusion has historically shown better long-term clinical outcomes than decompression alone, particularly when dynamic instability (>3 mm translation on flex/ext views) is present.

Question 15

A 48-year-old manual laborer presents with anterior shoulder pain and popping. MRI arthrogram demonstrates an isolated Type II SLAP lesion. He has no other rotator cuff pathology. After 4 months of failed physical therapy, surgical intervention is planned. What is the most appropriate surgical procedure for this patient?





Explanation

In patients over the age of 40 (especially those with physically demanding jobs), primary biceps tenodesis has been shown to yield higher satisfaction rates, lower complication rates, and a more reliable return to work compared to arthroscopic SLAP repair, which carries a higher risk of postoperative stiffness and persistent pain in this demographic.

Question 16

A 35-year-old female presents with a large, destructive lytic lesion in her distal radius with cortical breakthrough. Biopsy confirms a Giant Cell Tumor (GCT) of bone. Neoadjuvant therapy with denosumab is considered to downstage the tumor prior to curettage. What is the specific mechanism of action of denosumab in treating this lesion?





Explanation

Denosumab is a fully human monoclonal antibody that binds directly to the Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL). In Giant Cell Tumor of bone, the neoplastic mononuclear stromal cells overexpress RANKL, which recruits and activates the reactive multinucleated giant cells (osteoclast-like cells) responsible for bone destruction. Denosumab inhibits this interaction.

Question 17

A 28-year-old female sustains a twisting injury to her midfoot. Weight-bearing radiographs reveal a 3 mm diastasis between the base of the first and second metatarsals, with no obvious fractures (purely ligamentous Lisfranc injury). Which of the following treatments provides the best long-term functional outcome and lowest reoperation rate for this specific injury pattern?





Explanation

Multiple studies (including the landmark paper by Ly and Coetzee, 2006) have demonstrated that primary arthrodesis of the medial columns (1st, 2nd, and sometimes 3rd TMT joints) yields better long-term functional outcomes and significantly lower rates of reoperation and subsequent arthritis compared to ORIF in cases of purely ligamentous Lisfranc injuries.

Question 18

Highly cross-linked ultra-high-molecular-weight polyethylene (UHMWPE) was developed to improve the longevity of total hip arthroplasty implants. While increasing the radiation dose during manufacturing increases cross-linking and dramatically reduces volumetric wear, it also has a detrimental effect on which of the following material properties?





Explanation

Increasing the cross-linking of UHMWPE (via gamma or electron beam irradiation) significantly decreases its volumetric wear rate. However, high levels of cross-linking alter the polymer chain mobility, which leads to a decrease in mechanical properties, specifically ultimate tensile strength, fatigue resistance, and fracture toughness.

Question 19

A 25-year-old male is admitted with a comminuted midshaft tibia fracture. Overnight, he requires escalating doses of IV opioids. On examination, his leg is tense, and he has severe pain with passive stretch of the extensor hallucis longus. His blood pressure is 110/70 mmHg. Intracompartmental pressure monitoring of the anterior compartment yields a reading of 45 mmHg. What is his Delta P, and what is the appropriate management?





Explanation

Delta P (ΔP) is defined as the Diastolic Blood Pressure minus the Intracompartmental Pressure. In this case, 70 mmHg (Diastolic BP) - 45 mmHg (Compartment Pressure) = 25 mmHg. A Delta P of less than 30 mmHg is an absolute indication for emergent four-compartment fasciotomy to prevent irreversible muscle and nerve necrosis.

Question 20

A 7-year-old boy is diagnosed with Legg-Calve-Perthes disease. According to the Herring Lateral Pillar Classification, which of the following radiographic findings represents a Type C pillar, and what does it signify?





Explanation

The Herring Lateral Pillar Classification is based on the height of the lateral pillar of the capital femoral epiphysis during the fragmentation stage. Type A: no involvement (100% height). Type B: >50% of lateral pillar height is maintained. Type C: <50% of lateral pillar height is maintained. Type C carries a poor prognosis and a high likelihood of a non-spherical femoral head at skeletal maturity, predisposing to early osteoarthritis.

Question 21

A 5-year-old girl with developmental dysplasia of the hip (DDH) presents with an acetabular index of 40 degrees and primarily anterolateral deficiency. The surgeon plans an incomplete pericapsular osteotomy that relies on the flexibility of the triradiate cartilage to hinge the acetabular roof downward. Which of the following osteotomies is being described?





Explanation

The Pemberton osteotomy is an incomplete pericapsular osteotomy that hinges on the triradiate cartilage, reducing the volume of the acetabulum while improving anterolateral coverage. The Salter osteotomy is a complete innominate osteotomy that hinges at the pubic symphysis. The Dega osteotomy is also incomplete but typically directs the roof laterally and posteriorly, commonly used in spastic dysplasia. The Chiari is a salvage capsular interposition osteotomy.

Question 22

A 55-year-old man of Asian descent presents with progressive clumsiness in his hands and a positive Hoffman's sign. A CT scan of the cervical spine confirms ossification of the posterior longitudinal ligament (OPLL). Which of the following conditions is most strongly associated with this pathology?





Explanation

OPLL has a strong association with Diffuse Idiopathic Skeletal Hyperostosis (DISH). Up to 50% of patients with OPLL also demonstrate radiographic evidence of DISH, and both conditions share similar metabolic and genetic predisposing factors, including associations with type 2 diabetes and obesity.

Question 23

A 48-year-old manual laborer presents with chronic wrist pain years after an untreated scapholunate ligament tear. Radiographs show joint space narrowing extending across the entire radioscaphoid articulation. The capitolunate and radiolunate joints appear completely preserved. What is the correct staging for this condition?





Explanation

Scapholunate Advanced Collapse (SLAC) occurs in predictable stages. Stage I involves arthrosis restricted to the radial styloid and scaphoid. Stage II involves the entire radioscaphoid joint. Stage III involves the capitolunate joint. The radiolunate joint is characteristically spared due to its concentric, spherical articulation.

Question 24

A 52-year-old diabetic patient presents with a swollen, erythematous, and warm foot. Radiographs demonstrate fragmentation of the tarsometatarsal joints, periarticular debris, and joint subluxation. There are no skin ulcerations. What is the most appropriate initial management?





Explanation

The patient is in Eichenholtz Stage I (Developmental/Fragmentation) of Charcot arthropathy. The mainstay of initial treatment for acute, active Charcot arthropathy is strict immobilization and offloading, most effectively achieved with a total contact cast (TCC), until the extremity progresses to the coalescence phase.

Question 25

A 25-year-old woman is diagnosed with a giant cell tumor (GCT) of the distal femur. Her surgeon considers neoadjuvant treatment with Denosumab prior to curettage to facilitate intralesional resection. What is the exact mechanism of action of Denosumab?





Explanation

Denosumab is a fully human monoclonal antibody that binds directly to the Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL), preventing it from binding to the RANK receptor on osteoclasts and their precursors. This effectively inhibits osteoclast-mediated bone destruction, which is the primary driver of osteolysis in Giant Cell Tumor of bone.

Question 26

During the physical examination of a patient with a knee injury, the dial test reveals a 15-degree increase in external rotation of the tibia at 30 degrees of knee flexion compared to the uninjured side. However, at 90 degrees of knee flexion, the external rotation is symmetric bilaterally. What injury pattern does this indicate?





Explanation

The dial test assesses the integrity of the posterolateral corner (PLC) and the posterior cruciate ligament (PCL). Increased external rotation (>10 degrees compared to the normal side) solely at 30 degrees indicates an isolated PLC injury. If increased external rotation is present at both 30 and 90 degrees, it indicates a combined PLC and PCL injury.

Question 27

A 30-year-old male is brought to the trauma bay following a high-speed motor vehicle collision. He has an anteroposterior compression (APC III) pelvic ring injury and is hemodynamically unstable. A pelvic binder is applied, but he remains hypotensive. FAST exam is negative. What is the most common anatomical source of massive hemorrhage in this clinical scenario?





Explanation

In severe pelvic ring disruptions, 80-90% of massive hemorrhage is venous in origin, primarily from the presacral venous plexus and bleeding from the cancellous bone surfaces. Arterial bleeding (e.g., superior gluteal, internal pudendal) accounts for only 10-20% of cases, though it may require specific interventions such as angioembolization if venous bleeding is controlled via pelvic packing/binder.

Question 28

Demineralized bone matrix (DBM) is commonly used in orthopedic procedures as a bone graft extender. Processing allograft bone into DBM preserves which primary biologic property for bone healing?





Explanation

Demineralized bone matrix (DBM) undergoes acid extraction of the mineralized phase, which exposes bone morphogenetic proteins (BMPs) and other growth factors. This confers osteoinductive properties to the graft. Because it lacks live cells, it is not osteogenic. While it provides minimal osteoconductive scaffold, its primary therapeutic advantage over cancellous chips is osteoinduction.

Question 29

A 12-year-old boy undergoes in-situ pinning for a stable Slipped Capital Femoral Epiphysis (SCFE) using a single cannulated screw. If the screw inadvertently penetrates the anterosuperior quadrant of the femoral head during the procedure, the patient is at highest risk for developing which of the following complications?





Explanation

Unrecognized joint penetration by the hardware during SCFE pinning is the leading cause of chondrolysis (rapid destruction of articular cartilage). The anterosuperior quadrant is the most common location for unrecognized penetration because the screw may appear to be within the head on standard AP and lateral views while actually protruding into the joint.

Question 30

In complex total hip arthroplasty, a dual mobility articulation may be utilized to decrease the risk of dislocation. The primary biomechanical mechanism by which a dual mobility construct prevents instability is:





Explanation

A dual mobility construct consists of a small femoral head captive within a larger polyethylene liner, which itself articulates freely within a highly polished metallic acetabular shell. This effectively increases the effective head size (the large poly liner acts as the head during extreme range of motion), thereby massively increasing the 'jump distance' required for the construct to dislocate.

Question 31

A hand surgeon is repairing a complete laceration of the flexor digitorum profundus (FDP) tendon in Zone II. According to biomechanical studies, the tensile strength of the repair before clinical failure is most directly proportional to which of the following factors?





Explanation

The overall tensile strength of a flexor tendon repair is most directly proportional to the number of core suture strands crossing the repair site (e.g., 4-strand vs 6-strand repairs). While epitendinous sutures improve gliding and add 10-20% strength, and locking loops improve grip, the primary determinant of load-to-failure is the number of core strands.

Question 32

A 68-year-old male presents with bilateral lower extremity pain with walking. You are attempting to distinguish between neurogenic claudication (due to lumbar spinal stenosis) and vascular claudication. Which of the following clinical findings strongly favors neurogenic claudication?





Explanation

Neurogenic claudication is classically relieved by lumbar flexion (e.g., leaning over a shopping cart, sitting, walking uphill), which opens the spinal canal and neural foramina. Vascular claudication is relieved simply by stopping the metabolic demand (standing stationary) and typically worsens with uphill walking due to increased muscle exertion.

Question 33

A 28-year-old man sustains a talar neck fracture following a fall from a height. Radiographs reveal a displaced fracture of the talar neck with subluxation of the subtalar joint, but the tibiotalar and talonavicular joints remain perfectly congruent. According to the Hawkins classification, what is the approximate historical risk of developing avascular necrosis (AVN) of the talar body?





Explanation

The patient has a Hawkins Type II talar neck fracture (subtalar subluxation/dislocation with intact ankle and talonavicular joints). The historical risk of AVN for a Hawkins II fracture is approximately 20-50% (commonly cited as 42%). Hawkins I (nondisplaced) is 0-10%; Hawkins III (subtalar + tibiotalar dislocation) is 50-100% (often ~90%); Hawkins IV (all 3 joints dislocated) is near 100%.

Question 34

During the correction of idiopathic congenital talipes equinovarus (clubfoot) using the Ponseti method, the deformities must be corrected in a specific anatomical sequence. Which of the following components is addressed LAST in the treatment algorithm?





Explanation

The Ponseti method follows the CAVE sequence: Cavus, Adductus, Varus, and Equinus. The equinus deformity is the last to be corrected, often requiring a percutaneous Achilles tenotomy to achieve adequate dorsiflexion before the final cast is applied.

Question 35

A 45-year-old female presents with symptomatic hallux valgus that has failed non-operative management. Weight-bearing radiographs reveal a Hallux Valgus Angle (HVA) of 42 degrees and an Intermetatarsal Angle (IMA) of 18 degrees. Based on these parameters, which of the following is the most appropriate surgical intervention?





Explanation

An Intermetatarsal Angle (IMA) > 15 degrees and a Hallux Valgus Angle (HVA) > 40 degrees constitute a severe hallux valgus deformity. A distal osteotomy (like a chevron) is insufficient to translate the metatarsal head enough to correct this large IMA. A proximal metatarsal osteotomy (or a Lapidus procedure) is required to achieve adequate correction.

Question 36

A 15-year-old boy presents with progressive thigh pain. Radiographs demonstrate a permeative diaphyseal lesion of the femur with an 'onion skin' periosteal reaction. A biopsy shows sheets of small round blue cells. Which chromosomal translocation is most characteristically associated with this tumor?





Explanation

The clinical, radiographic, and histologic findings describe Ewing Sarcoma. Over 85% of Ewing sarcomas are characterized by the t(11;22)(q24;q12) chromosomal translocation, which results in the EWS-FLI1 fusion gene. t(9;22) is seen in CML or extraskeletal myxoid chondrosarcoma; t(X;18) in synovial sarcoma; t(12;16) in myxoid liposarcoma; and t(2;13) in alveolar rhabdomyosarcoma.

Question 37

Three months after open reduction and internal fixation of a distal radius fracture with a volar locking plate, a patient develops a sudden inability to extend the interphalangeal joint of the thumb. What is the most common iatrogenic cause of this specific complication in the setting of volar plating?





Explanation

Rupture of the extensor pollicis longus (EPL) tendon after volar plating of the distal radius is most commonly caused by dorsal screw prominence. Screws that are too long penetrate the dorsal cortex and cause mechanical attrition of the EPL tendon within the third extensor compartment. Attrition over the distal edge of the volar plate affects flexor tendons (like the FPL).

Question 38

According to the 2018 International Consensus Meeting (ICM) criteria for Periprosthetic Joint Infection (PJI), which of the following findings is considered a MAJOR criterion that independently confirms the diagnosis of PJI?





Explanation

The 2018 ICM criteria establish two major criteria for definitive diagnosis of PJI: 1) Two positive periprosthetic cultures with phenotypically identical organisms, or 2) A sinus tract communicating with the joint. Purulence, elevated inflammatory markers, and a single positive culture serve only as minor criteria.

Question 39

Biomechanical studies have demonstrated that an un-repaired complete radial tear of the medial meniscus posterior root alters the contact mechanics and joint kinematics of the knee most similarly to which of the following conditions?





Explanation

A posterior root tear of the medial meniscus completely disrupts the hoop stresses that allow the meniscus to convert axial loads into circumferential tension. Biomechanically, this failure of hoop stress makes the knee function almost identically to a knee that has undergone a total medial meniscectomy, leading to rapid articular cartilage wear and osteoarthritis.

Question 40

Bone Morphogenetic Proteins (BMPs) play a crucial role in osteoinduction and fracture healing. Biologically, BMPs are members of which of the following larger signaling superfamilies?





Explanation

Bone Morphogenetic Proteins (BMPs) are a group of growth factors structurally classified as part of the Transforming Growth Factor-beta (TGF-beta) superfamily. They bind to serine/threonine kinase receptors on the cell surface and mediate downstream signaling via Smad proteins to induce differentiation of mesenchymal stem cells into osteoblasts.

Question 41

A 12-year-old female presents with back pain and a slip angle of 55 degrees on standing lateral radiographs, consistent with high-grade dysplastic spondylolisthesis. Which of the following is the most characteristic physical exam finding associated with this condition?





Explanation

High-grade spondylolisthesis in children is classically accompanied by severe hamstring tightness. This leads to a typical waddling gait with knees bent and a retroverted pelvis, known as the Phalen-Dickson sign.

Question 42

In a Young-Burgess Anterior Posterior Compression Type III (APC III) pelvic ring injury, which of the following ligamentous complexes is definitively disrupted compared to an APC II injury?





Explanation

APC II involves disruption of the anterior sacroiliac, sacrotuberous, and sacrospinous ligaments, while the posterior sacroiliac ligaments remain intact, maintaining some vertical stability. APC III involves complete disruption of both anterior and posterior sacroiliac ligaments, causing complete multidirectional pelvic instability.

Question 43

A 65-year-old man undergoes primary THA with a ceramic-on-ceramic bearing. At 2-year follow-up, he complains of a reproducible squeaking noise when walking. Which of the following factors is most strongly associated with squeaking in ceramic-on-ceramic total hip arthroplasty?





Explanation

Squeaking in ceramic-on-ceramic THA is highly associated with edge loading, which typically occurs due to acetabular component malposition (such as steep inclination or improper anteversion). This leads to microseparation and stripe wear, producing the characteristic squeak.

Question 44

A 32-year-old manual laborer presents with dorsal wrist pain. Radiographs reveal sclerosis and fragmentation of the lunate without carpal collapse. Ulnar variance is determined to be minus 3 mm. Which of the following surgical interventions is most appropriate for this Lichtman Stage II Kienböck's disease?





Explanation

In Kienböck's disease with ulnar minus variance and no carpal collapse (Stage II or IIIA), joint-leveling procedures such as a radial shortening osteotomy (or ulnar lengthening) are indicated to decrease the compressive forces across the radiolunate joint and decompress the lunate.

Question 45

A 14-year-old boy presents with a painful, swollen thigh. Radiographs show a permeative diaphyseal lesion with a periosteal 'onion-skin' reaction in the femur. Biopsy confirms Ewing sarcoma. Which of the following chromosomal translocations is most characteristic of this diagnosis?





Explanation

Ewing sarcoma is classically associated with the t(11;22)(q24;q12) translocation, resulting in the EWS-FLI1 fusion protein. t(X;18) is associated with Synovial Sarcoma; t(12;16) with Myxoid Liposarcoma; t(9;22) with Extraskeletal Myxoid Chondrosarcoma; and t(2;13) with Alveolar Rhabdomyosarcoma.

Question 46

A 6-week-old female is treated with a Pavlik harness for developmental dysplasia of the hip. At the 1-week follow-up, the mother notes the infant has stopped kicking her left leg, and the knee remains extended. Which of the following is the most likely cause?





Explanation

Femoral nerve palsy is a known complication of the Pavlik harness, typically caused by hyperflexion when the anterior straps are too tight. It presents with decreased active knee extension. The treatment is adjusting the straps to reduce flexion, and it usually resolves spontaneously.

Question 47

During the incorporation of a cortical bone allograft, what is the term used to describe the process where osteoclasts resorb the dead bone and osteoblasts simultaneously lay down new bone in the cutting cone?





Explanation

Creeping substitution is the process by which cortical bone grafts are incorporated. It involves a cutting cone of osteoclasts resorbing the necrotic host bone, closely followed by osteoblasts depositing new viable bone along the pathways.

Question 48

A 24-year-old football player sustains a valgus blow to the knee. MRI shows a complete tear of the medial collateral ligament (MCL) and a tear of the posterior oblique ligament (POL). What is the primary biomechanical function of the POL?





Explanation

The posterior oblique ligament (POL) acts as a primary restraint to internal rotation of the tibia, particularly near full extension, and it provides secondary restraint to valgus stress.

Question 49

A 55-year-old diabetic patient presents with a warm, swollen, erythematous foot. Radiographs reveal fragmentation of the midfoot, periarticular debris, and subluxation of the tarsometatarsal joints. According to the Eichenholtz classification, what stage is this patient in?





Explanation

Eichenholtz Stage I is the developmental or fragmentation stage, characterized clinically by a red, hot, swollen foot and radiographically by bony debris, fragmentation, and joint subluxation. Stage II shows absorption of debris and early coalescence, while Stage III shows remodeling.

Question 50

You are treating a 45-year-old male with a posteromedial shear fracture of the tibial plateau (Schatzker IV variant). Which surgical approach is most appropriate for direct visualization and buttress plating of this specific fragment?





Explanation

The posteromedial fragment of a tibial plateau fracture requires a posteromedial approach. The surgical interval is typically between the medial head of the gastrocnemius (retracted laterally) and the pes anserinus (retracted medially/anteriorly) to allow optimal placement of a posterior buttress plate.

Question 51

A 50-year-old man presents with neck pain radiating down his right arm. Examination reveals weakness in wrist flexion and finger extension, with diminished triceps reflex and numbness in the middle finger. Which cervical nerve root is most likely compressed?





Explanation

A C7 radiculopathy is characterized by weakness in the triceps, wrist flexors, and finger extensors. The triceps reflex is often diminished, and sensory changes typically involve the middle finger.

Question 52

A 68-year-old woman presents 1 year after a posterior-stabilized total knee arthroplasty with a painful catching sensation when extending her knee from a flexed position. What is the most likely diagnosis?





Explanation

Patellar clunk syndrome occurs primarily in posterior-stabilized TKA. A fibrotic nodule forms on the undersurface of the quadriceps tendon and catches in the intercondylar box of the femoral component during active extension from a flexed position, producing a painful clunk.

Question 53

Prophylactic pinning of the contralateral hip in a patient with a unilateral Slipped Capital Femoral Epiphysis (SCFE) is most strongly indicated in a patient with which of the following underlying conditions?





Explanation

Prophylactic pinning of the contralateral hip is highly recommended in patients with endocrine disorders (such as hypothyroidism, panhypopituitarism, or renal osteodystrophy) or those with prior radiation therapy, as they have a significantly higher risk of bilateral involvement compared to idiopathic SCFE.

Question 54

Following a Zone II flexor tendon repair, which rehabilitation protocol initially uses dynamic flexion traction via rubber bands and active extension within the limits of a dorsal blocking splint?





Explanation

The Kleinert protocol utilizes a dorsal blocking splint with dynamic rubber band traction pulling the digits into flexion, allowing active extension against the resistance of the rubber bands. The Duran protocol, in contrast, involves controlled passive motion (passive flexion and passive extension).

Question 55

Galvanic corrosion in orthopedic implants is most likely to occur when which of the following combinations of metals are placed in direct physical contact within the body?





Explanation

Galvanic corrosion occurs when two dissimilar metals with different anodic indices are in electrical contact within an electrolytic environment (like body fluid). Stainless steel and titanium are significantly dissimilar, leading to a galvanic couple where the less noble metal (stainless steel) undergoes accelerated corrosion.

Question 56

A 22-year-old collegiate baseball pitcher presents with posterior shoulder pain during the late cocking phase of throwing. Examination reveals a significant loss of internal rotation (GIRD) and a positive relocation test. MRI shows undersurface fraying of the posterior supraspinatus and anterior superior labrum. What is the most likely diagnosis?





Explanation

Internal impingement (posterosuperior impingement) occurs in overhead athletes during maximal abduction and external rotation (the late cocking phase). The undersurface of the posterior supraspinatus/anterior infraspinatus impinges against the posterosuperior glenoid labrum.

Question 57

A 65-year-old female sustains a distal radius fracture. Radiographs show a volar marginal articular fracture fragment with volar subluxation of the carpus. Which of the following eponymous terms correctly describes this fracture pattern?





Explanation

A volar Barton fracture is a shear fracture of the volar articular margin of the distal radius associated with volar subluxation or dislocation of the radiocarpal joint. A Smith fracture is an extra-articular distal radius fracture with volar angulation.

Question 58

A 60-year-old male is diagnosed with a Grade II conventional chondrosarcoma of the proximal femur. Which of the following is the standard of care for surgical treatment of this lesion?





Explanation

Conventional chondrosarcomas (Grade II and III) are relatively resistant to both chemotherapy and radiotherapy. The standard treatment is wide surgical resection with negative margins. Intralesional curettage is reserved for benign cartilaginous lesions or select Grade I chondrosarcomas (atypical cartilaginous tumors) in the appendicular skeleton.

Question 59

In a 2-year-old child, why does acute hematogenous osteomyelitis of the proximal femur carry a high risk of rapidly developing into septic arthritis of the hip?





Explanation

In the proximal femur (as well as the proximal humerus, lateral malleolus, and radial neck), the metaphysis is located within the joint capsule (intra-articular). Therefore, an infection starting in the metaphyseal bone can easily breach the thin cortex and directly enter the joint space, causing septic arthritis.

Question 60

According to Lewinnek, what is the historically described 'safe zone' for acetabular component positioning in total hip arthroplasty to minimize the risk of dislocation?





Explanation

The classic Lewinnek safe zone for acetabular cup placement is 40° ± 10° of lateral opening (inclination) and 15° ± 10° of anteversion. Cups placed outside this zone historically have a higher rate of dislocation, although recent literature questions the absolute validity of a single safe zone for all patients.

Question 61

A 15-year-old male presents with increasing middle back pain and a visible rounding of his spine. Standing lateral radiographs reveal thoracic kyphosis of 60 degrees. According to the Sorensen criteria, which of the following radiographic findings must be present to establish a definitive diagnosis of Scheuermann's kyphosis?





Explanation

Scheuermann's disease is a rigid structural thoracic or thoracolumbar kyphosis. The Sorensen criteria mandate that there must be anterior wedging of greater than 5 degrees in at least three consecutive vertebrae. While Schmorl's nodes and apophyseal ring irregularities are commonly associated radiographic findings, they are not strictly required by the diagnostic criteria.

Question 62

During a posterior-stabilized total knee arthroplasty, the surgeon uses spacer blocks to assess gap kinematics. With the trial components in place, the extension gap is perfectly symmetric and stable. However, when the knee is flexed to 90 degrees, the joint is grossly unstable both medially and laterally. Which of the following technical errors is the most likely cause of this isolated flexion gap looseness?





Explanation

In total knee arthroplasty, the size of the femoral component dictates the anteroposterior (AP) dimension of the femur, which directly influences the flexion gap. An undersized femoral component decreases the AP dimension, leading to a loose flexion gap. Because the distal femoral resection is unchanged, the extension gap remains stable.

Question 63

A 35-year-old male sustains a vertically unstable (Tile C) pelvic ring disruption in a motor vehicle collision. He arrives at the trauma bay hypotensive and tachycardic. To control severe venous bleeding, emergent preperitoneal pelvic packing is performed. Into which specific anatomic space are the laparotomy sponges packed?





Explanation

Preperitoneal pelvic packing is an effective method for controlling venous hemorrhage in severe pelvic fractures. Through a midline incision, the rectus abdominis is split and packs are placed directly into the preperitoneal space (the retropubic space of Retzius) along the pelvic brim and paravesical spaces. It avoids entry into the peritoneal cavity.

Question 64

An electromyographic (EMG) study reveals a Martin-Gruber anastomosis. Which of the following accurately describes the anatomic pathway of this common neural communication?





Explanation

A Martin-Gruber anastomosis is a common anatomical variant (present in roughly 15-20% of individuals) in which motor nerve fibers communicate from the median nerve (or its anterior interosseous branch) to the ulnar nerve in the proximal forearm. This anomaly can complicate the diagnosis of ulnar neuropathy at the elbow.

Question 65

A 14-year-old boy presents with a painful, swollen left mid-thigh. Radiographs reveal a permeative, destructive diaphyseal lesion of the femur with a laminated 'onion-skin' periosteal reaction. Biopsy demonstrates a proliferation of small round blue cells. Which of the following chromosomal translocations is the most common genetic hallmark of this tumor?





Explanation

The clinical, radiographic, and histological findings are classic for Ewing sarcoma. The most common chromosomal translocation in Ewing sarcoma is t(11;22)(q24;q12), which fuses the EWSR1 gene on chromosome 22 with the FLI1 gene on chromosome 11. t(X;18) is seen in synovial sarcoma, t(2;13) in alveolar rhabdomyosarcoma, and t(12;16) in myxoid liposarcoma.

Question 66

When evaluating the viscoelastic properties of tendons and ligaments, which of the following statements best defines the biomechanical phenomenon of 'stress relaxation'?





Explanation

Viscoelastic materials exhibit time-dependent behavior. 'Stress relaxation' is the decrease in stress (load) observed over time when a tissue is held at a constant strain (length). In contrast, 'creep' is the increase in strain (deformation) over time under a constant load. Energy lost as heat is 'hysteresis'.

Question 67

During a medial patellofemoral ligament (MPFL) reconstruction for recurrent patellar instability, the surgeon seeks the anatomic femoral attachment site (Schöttle's point) using fluoroscopy. Anatomically, where does the MPFL originate on the medial femur?





Explanation

The anatomic femoral origin of the MPFL is located in a saddle-shaped depression between the adductor tubercle (proximally) and the medial epicondyle (distally and anteriorly). On a perfect lateral radiograph, Schöttle's point is located 1 mm anterior to the posterior cortex extension line, 2.5 mm distal to the posterior origin of the medial femoral condyle, and proximal to the level of the posterior point of Blumensaat's line.

Question 68

A 25-year-old male is involved in a high-speed motor vehicle collision. CT of the cervical spine shows a traumatic spondylolisthesis of the axis (Hangman's fracture) with severe angulation but minimal translation of C2 on C3. MRI reveals a disrupted C2-3 disc space and an intact anterior longitudinal ligament. This is classified as a Levine-Edwards Type IIA fracture. What is the most appropriate initial management?





Explanation

A Levine-Edwards Type IIA Hangman's fracture involves severe angulation with minimal translation and is caused by a flexion-distraction injury mechanism. The C2-3 disc is torn, but the ALL is intact. Longitudinal traction is strictly contraindicated as it will distract the C2-3 space and exacerbate instability. Treatment involves gentle reduction with slight compression and extension, followed by Halo vest immobilization.

Question 69

A 60-year-old man presents with a painful, severe, and rigid flatfoot deformity. Examination reveals an inability to perform a single-leg heel raise, and the heel remains in fixed valgus on double-leg heel raise. Weight-bearing radiographs demonstrate profound osteoarthritis of the subtalar, talonavicular, and calcaneocuboid joints. What is the most appropriate definitive surgical intervention?





Explanation

This patient has a Stage III posterior tibial tendon dysfunction (PTTD), which is characterized by a fixed, rigid flatfoot deformity and degenerative joint disease (osteoarthritis) of the hindfoot complex. The gold standard surgical treatment for Stage III PTTD with advanced degenerative changes in the subtalar, talonavicular, and calcaneocuboid joints is a triple arthrodesis.

Question 70

In the management of Slipped Capital Femoral Epiphysis (SCFE), prophylactic in situ pinning of the asymptomatic contralateral hip is widely debated. However, there is strong consensus to perform prophylactic pinning in which of the following patient presentations?





Explanation

Patients with underlying endocrine or metabolic disorders (such as hypothyroidism, growth hormone deficiency, or renal osteodystrophy) or a history of pelvic radiation are at a substantially higher risk for bilateral SCFE (up to 100% in some metabolic conditions). In these high-risk cohorts, prophylactic pinning of the contralateral hip is strongly recommended regardless of age or gender.

Question 71

In total hip arthroplasty, the use of highly cross-linked polyethylene (HXLPE) has significantly reduced volumetric wear rates compared to conventional ultra-high molecular weight polyethylene (UHMWPE). However, the cross-linking and subsequent thermal processing alter the mechanical properties of the material. What is the primary mechanical disadvantage of highly cross-linked polyethylene?





Explanation

Irradiation of polyethylene creates cross-links that dramatically reduce wear. However, the cross-linking process decreases ultimate tensile strength, yield strength, ductility, and fracture toughness (fatigue crack propagation resistance). Thermal treatment (remelting) is used to eliminate free radicals to prevent oxidation, but it further decreases mechanical strength. Therefore, HXLPE is more brittle than conventional PE.

Question 72

A 'terrible triad' injury of the elbow involves a posterior elbow dislocation, radial head fracture, and coronoid fracture. During the standard surgical reconstruction via a single lateral approach, what is the generally recommended sequence of fixation to restore elbow stability?





Explanation

The standard surgical algorithm for a terrible triad injury involves working deep to superficial from the lateral side. First, the coronoid fracture (or anterior capsule) is repaired. Next, the radial head is either fixed or replaced. Then, the lateral collateral ligament (LCL) complex is repaired to the lateral epicondyle. The medial collateral ligament (MCL) is only addressed if the elbow remains grossly unstable after these three steps.

Question 73

Vitamin D plays a critical role in bone metabolism. Following synthesis in the skin or absorption from the gut, it undergoes two sequential hydroxylations to become biologically active. Which specific enzyme is responsible for the final conversion to 1,25-dihydroxyvitamin D (calcitriol)?





Explanation

Vitamin D is first hydroxylated in the liver by 25-hydroxylase to form 25-hydroxyvitamin D (calcidiol). The final, rate-limiting hydroxylation occurs in the proximal tubules of the kidney, catalyzed by the enzyme 1-alpha-hydroxylase, which converts it to 1,25-dihydroxyvitamin D (calcitriol), its most active form. This step is stimulated by PTH.

Question 74

Flexor tendon lacerations of the hand are categorized into anatomic zones to guide prognosis and treatment. Which zone, containing both the flexor digitorum superficialis (FDS) and flexor digitorum profundus (FDP) tendons within a tight fibro-osseous sheath, is historically referred to as 'no man's land'?





Explanation

Zone II extends from the distal palmar crease (the proximal edge of the A1 pulley) to the insertion of the FDS tendon in the middle phalanx. Because both the FDP and FDS tendons lie closely together within the narrow fibro-osseous flexor sheath, primary repair in this area historically had high rates of dense adhesions and poor functional outcomes, earning it the moniker 'no man's land' by Bunnell.

Question 75

A 65-year-old male presents with deteriorating handwriting, dropping objects, and a subjective feeling of lower extremity stiffness. Physical examination demonstrates hyperreflexia in the patellar and Achilles tendons. Striking the distal brachioradialis tendon elicits no reflex in the brachioradialis itself, but produces a brisk spontaneous flexion of the fingers. This specific finding (the inverted brachioradialis reflex) indicates spinal cord compression at which specific level?





Explanation

The inverted brachioradialis reflex is highly localizing for cervical myelopathy at the C5-C6 disc space (affecting the C6 nerve root). The compressive lesion causes a lower motor neuron lesion at C6 (hence the absent brachioradialis reflex) while simultaneously causing an upper motor neuron lesion to the spinal tracts supplying lower levels, leading to hyperactive finger flexion (C8/T1).

Question 76

A 24-year-old elite overhead throwing athlete presents with deep shoulder pain and mechanical catching sensations. MR arthrography suggests a SLAP (Superior Labrum Anterior Posterior) tear. Diagnostic arthroscopy reveals a Type II SLAP lesion. Which of the following accurately describes a Type II SLAP tear according to the Snyder classification?





Explanation

Snyder classification of SLAP tears: Type I is degenerative fraying of the superior labrum with an intact biceps anchor. Type II (the most common type requiring repair in athletes) is pathologic detachment of the superior labrum and biceps anchor from the superior glenoid. Type III is a bucket-handle tear of the labrum with an intact biceps anchor. Type IV is a bucket-handle tear extending into the biceps tendon.

Question 77

A 32-year-old male sustains a high-energy vertical shear injury to his foot and ankle. Radiographs reveal a displaced talar neck fracture with subluxation of the subtalar joint and complete dislocation of the tibiotalar joint. According to the Hawkins classification, this is a Type III fracture. What is the approximate reported incidence of avascular necrosis (AVN) of the talar body associated with this specific injury pattern?





Explanation

Hawkins Type III talar neck fractures involve displacement of the talar neck with dislocation of both the subtalar and tibiotalar joints. Because all three major blood supplies (artery of the tarsal canal, deltoid branches, and artery of the sinus tarsi) are disrupted, the risk of AVN of the talar body is extremely high, widely reported in classical literature as 70 to 100%.

Question 78

A 4-week-old female infant is diagnosed with developmental dysplasia of the hip (DDH) after a positive Ortolani maneuver. A Pavlik harness is applied. At the one-week follow-up, it is noted that the anterior straps are excessively tight, holding the hips in over 120 degrees of flexion. Which peripheral nerve is most at risk for palsy due to this specific positioning error?





Explanation

A common and severe complication of the Pavlik harness is femoral nerve palsy, which is typically caused by hyperflexion of the hips (excessively tight anterior straps) compressing the nerve against the inguinal ligament. Excessive abduction (tight posterior straps) is associated with avascular necrosis of the femoral head.

Question 79

Periprosthetic joint infections are notoriously difficult to eradicate due to the formation of bacterial biofilms on the implant surface. While the exopolysaccharide matrix provides a physical barrier, what is considered the primary biological mechanism by which biofilms convey profound resistance to systemic bactericidal antibiotics?





Explanation

The most significant mechanism of antibiotic tolerance in biofilms is the phenotypic shift of bacteria deep within the matrix into a metabolically inactive or dormant state, known as 'persister' cells. Because most bactericidal antibiotics (like beta-lactams) target cellular processes that occur during active replication (e.g., cell wall synthesis), these dormant cells are inherently immune to the drug's mechanism of action.

Question 80

A 68-year-old male presents with a pathologic fracture of the proximal humerus. Radiographs reveal a large 'punched-out' lytic lesion. Laboratory workup shows hypercalcemia, an elevated serum creatinine, and a monoclonal spike on serum protein electrophoresis (SPEP). In the pathophysiology of this disease, what is the primary mechanism driving the extensive osteolysis?





Explanation

The patient has Multiple Myeloma. The characteristic osteolytic bone lesions in multiple myeloma are driven by marked osteoclast activation combined with osteoblast inhibition. Myeloma cells do not destroy bone directly; instead, they secrete various factors, most notably RANKL (Receptor Activator of Nuclear factor Kappa-B Ligand) and MIP-1 alpha (Macrophage Inflammatory Protein-1 alpha), which potently stimulate osteoclast differentiation and activity. They also suppress osteoblast function via DKK-1.

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