An 8-year-old boy has had pain and swelling around the right knee for the past 4 weeks. He recalls bumping it about 4 weeks ago. He has no pain in other joints, and denies any fevers, chills, or other symptoms. A radiograph is shown in Figure 13. Laboratory studies show a WBC count of 9,700/mm3, an erythrocyte sedimentation rate of 18 mm/h, and a C-reactive protein level of 3.7 mg/L. What is the next most appropriate step in management?
<img alt="General Orthopedics Board Review 2026: High-Yield MCQs (Set 6) - Figure 120" class="q-img mcq-img" height="393" loading="lazy" onclick="window.open(this.src)" src="/media/mcq-images/25/general-orthopedics-2026-set-6-mcqs-4061-fig-120.webp" title="Click to enlarge" width="255"/>
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<span class="opt-char">A</span>
<span>Chemotherapy and radiation therapy</span>
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<span class="opt-char">B</span>
<span>Intravenous antibiotics, protected weight bearing, and a repeat C-reactive protein after improvement</span>
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<span class="opt-char">C</span>
<span>Open biopsy and debridement of the site, followed by intravenous antibiotics</span>
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<span class="opt-char">D</span>
<span>Technetium Tc 99m bone scan</span>
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<span class="opt-char">E</span>
<span>Empiric oral antibiotics and repeat laboratory studies in 1 week</span>
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<span class="exp-title">Detailed Explanation</span><div markdown="1">The history and laboratory findings are consistent with osteomyelitis of the patella. The radiograph reveals bone destruction in the patella; therefore, the next most appropriate step is open biopsy and debridement of the site. Aspiration of the knee joint may be needed to rule out septic arthritis prior to patellar debridement. With this amount of bone destruction, surgical debridement is helpful to obtain cultures and to remove necrotic material. Administering antibiotics without any prior culture increases the risk of negative cultures later and a potentially incorrect choice of antibiotic. A neoplasm should be included in the differential. It would be inappropriate to initiate chemotherapy and radiation therapy without a biopsy-confirmed diagnosis. A bone scan is likely to demonstrate uptake, but radiographs have already localized the abnormality to the patella. Morrisy RT: Bone and joint sepsis, in Morrissy RT, Weinstein SL (eds): Lovell and Winter's Pediatric Orthopaedics, ed 5. Philadelphia, PA, Lippincott Williams & Wilkins, 2001, pp 466-470.
<strong>References:</strong><ul><li>Dormans JP, Drummond DS: Pediatric hematogenous osteomyelitis: New trends in presentation, diagnosis, and treatment. J Am Acad Orthop Surg 1994;2:333-341.</li></ul>