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Question 541

Topic: 3. Adult Reconstruction (Hip & Knee)

A 55-year-old male who underwent a metal-on-metal (MOM) total hip arthroplasty 6 years ago presents with progressive fatigue, shortness of breath, and bilateral hearing loss. His local hip examination is relatively benign, but laboratory studies reveal elevated metal ion levels. Toxicity from which of the following metal ions is most directly responsible for his systemic presentation?

. Titanium
. Chromium
. Cobalt
. Molybdenum
. Nickel

Correct Answer & Explanation

. Cobalt


Explanation

Cobalt toxicity from MOM articulations can present with systemic manifestations, including cardiomyopathy, hypothyroidism, and neuro-ocular toxicity (e.g., hearing loss, visual changes). While chromium levels also rise, cobalt is primarily responsible for systemic arthroprosthetic cobaltism.

Question 542

Topic: 3. Adult Reconstruction (Hip & Knee)

When counseling patients on metal-on-metal (MOM) hip resurfacing, the orthopedic surgeon must consider patient-specific and implant-specific risk factors for early failure. Which of the following profiles represents the highest risk for developing adverse local tissue reactions (ALTR) and early failure?

. A 55-year-old male with primary osteoarthritis and a 54 mm component size
. A 60-year-old male with avascular necrosis and a 52 mm component size
. A 45-year-old female with developmental dysplasia and a 46 mm component size
. A 50-year-old male with post-traumatic arthritis and a 56 mm component size
. A 40-year-old male with primary osteoarthritis and a 58 mm component size

Correct Answer & Explanation

. A 45-year-old female with developmental dysplasia and a 46 mm component size


Explanation

Risk factors for MOM hip resurfacing failure and adverse local tissue reactions (ALTR) include female sex, smaller femoral component size (<50 mm), and developmental dysplasia of the hip. Smaller components are more prone to edge loading, leading to increased metal wear.

Question 543

Topic: 3. Adult Reconstruction (Hip & Knee)

A 49-year-old female is 5 years status post metal-on-metal hip resurfacing. She reports new-onset groin pain and a mechanical clicking sensation. Radiographs show optimally positioned components with no lucencies. Serum cobalt is 11 ppb. What is the most appropriate next step in evaluation?

. Non-contrast computed tomography (CT) of the pelvis
. Technetium-99m bone scan
. Metal Artifact Reduction Sequence (MARS) MRI
. Diagnostic fluoroscopic-guided hip aspiration
. Positron emission tomography (PET) scan

Correct Answer & Explanation

. Metal Artifact Reduction Sequence (MARS) MRI


Explanation

MARS MRI is the gold standard imaging modality to evaluate for adverse local tissue reactions (ALTR) or pseudotumors in symptomatic patients with MOM hip implants and elevated metal ions. It accurately assesses the extent of soft tissue and abductor damage.

Question 544

Topic: 3. Adult Reconstruction (Hip & Knee)

During revision of a failed metal-on-metal hip resurfacing for an extensive pseudotumor, tissue samples are sent for histopathological analysis. Which of the following findings is most characteristic of an Aseptic Lymphocytic Vasculitis-Associated Lesion (ALVAL)?

. Abundant neutrophils with intracellular gram-positive cocci
. Sheets of foamy macrophages containing birefringent polymeric wear debris
. Extensive perivascular infiltration of T-lymphocytes and tissue necrosis
. Multinucleated giant cells containing particulate ceramic debris
. Monoclonal proliferation of atypical plasma cells

Correct Answer & Explanation

. Extensive perivascular infiltration of T-lymphocytes and tissue necrosis


Explanation

ALVAL is considered a delayed-type IV hypersensitivity reaction to metal ions (primarily cobalt and chromium). Histologically, it is hallmarked by an extensive perivascular infiltrate of T-lymphocytes, fibrin exudation, and tissue necrosis.

Question 545

Topic: 3. Adult Reconstruction (Hip & Knee)

A 45-year-old active male underwent a total hip arthroplasty with a ceramic-on-ceramic bearing. Two years postoperatively, he complains of a new-onset squeaking noise from the hip during gait, without pain. What is the most significant risk factor for this phenomenon?

. Femoral stem subsidence
. Acetabular component malposition
. Prosthetic joint infection
. Leg length discrepancy
. Aseptic loosening of the femoral stem

Correct Answer & Explanation

. Acetabular component malposition


Explanation

Squeaking is a known complication of ceramic-on-ceramic bearings, occurring in up to 10% of patients. It is most strongly associated with edge loading due to acetabular component malposition, such as excessive anteversion or inclination.

Question 546

Topic: 3. Adult Reconstruction (Hip & Knee)
Which mechanism of wear is most responsible for the generation of submicron polyethylene particles that precipitate osteolysis in conventional ultra-high-molecular-weight polyethylene (UHMWPE) total hip arthroplasty components?
. Abrasive wear
. Adhesive wear
. Third-body wear
. Fatigue wear
. Corrosive wear

Correct Answer & Explanation

. Adhesive wear


Explanation

Adhesive wear is the primary mechanism generating millions of submicron UHMWPE particles (0.1 to 1.0 microns) that are easily phagocytosed by macrophages. This initiates the biological cascade leading to osteolysis and aseptic loosening.

Question 547

Topic: 3. Adult Reconstruction (Hip & Knee)

According to the Musculoskeletal Infection Society (MSIS) and International Consensus Meeting (ICM) criteria, which of the following findings is considered a definitive major criterion for diagnosing a periprosthetic joint infection (PJI)?

. Elevated serum ESR and CRP
. Purulence in the affected joint
. A single positive intraoperative tissue culture
. A communicating sinus tract to the prosthesis
. Synovial fluid leukocyte count > 3,000 cells/uL

Correct Answer & Explanation

. A communicating sinus tract to the prosthesis


Explanation

The two major criteria for definitive diagnosis of PJI are the presence of a sinus tract communicating with the prosthesis and the isolation of the same microorganism from two or more distinct cultures obtained from the affected joint.

Question 548

Topic: 3. Adult Reconstruction (Hip & Knee)

A 70-year-old female presents with her third posterior dislocation 4 weeks after a primary total hip arthroplasty (THA). Radiographs and CT demonstrate the acetabular component is placed in 10 degrees of retroversion and 40 degrees of abduction. The femoral component is well-fixed with 15 degrees of anteversion. What is the definitive management?

. Closed reduction and hip abduction bracing for 12 weeks
. Revision of the femoral component to increase anteversion
. Revision of the acetabular component to increase anteversion
. Placement of a constrained polyethylene liner
. Conversion to an excision arthroplasty (Girdlestone)

Correct Answer & Explanation

. Revision of the acetabular component to increase anteversion


Explanation

The patient has recurrent posterior instability due to acetabular retroversion (malposition). The definitive treatment is revision of the acetabular component to achieve proper anteversion (typically 15-20 degrees) to restore stability.

Question 549

Topic: 3. Adult Reconstruction (Hip & Knee)

During an ABOS oral exam, you are presented with a 65-year-old female who is 8 years status post a metal-on-metal total hip arthroplasty. She complains of new-onset groin pain and a palpable mass. Laboratory studies show significantly elevated serum cobalt and chromium levels. Which of the following imaging modalities is MOST appropriate to evaluate the extent of the suspected adverse local tissue reaction (ALTR)?

. Bone scintigraphy (Bone Scan)
. Positron emission tomography (PET)
. Computed tomography (CT) with intravenous contrast
. Metal artifact reduction sequence (MARS) MRI
. Standard ultrasound of the hip

Correct Answer & Explanation

. Metal artifact reduction sequence (MARS) MRI


Explanation

MARS MRI is the gold standard for evaluating adverse local tissue reactions (ALTR) or pseudotumors around metal-on-metal implants. It clearly defines the soft tissue mass, fluid collections, and the extent of muscle destruction, which is critical for preoperative planning.

Question 550

Topic: 3. Adult Reconstruction (Hip & Knee)

Six months after a total knee arthroplasty, a 70-year-old patient presents with a draining sinus tract communicating with the joint. What is the gold standard surgical management for this presentation?

. One-stage revision arthroplasty
. Two-stage revision arthroplasty with an antibiotic spacer
. Irrigation and debridement with polyethylene exchange (DAIR)
. Chronic suppressive oral antibiotics
. Arthroscopic irrigation and debridement

Correct Answer & Explanation

. Two-stage revision arthroplasty with an antibiotic spacer


Explanation

A draining sinus tract communicating with the prosthesis is a definitive sign of chronic periprosthetic joint infection. The gold standard treatment in North America is a two-stage revision arthroplasty.

Question 551

Topic: 3. Adult Reconstruction (Hip & Knee)

A 40-year-old man presents with a chronic, rigid mallet deformity of his index finger 2 years after an untreated injury. He complains of pain and difficulty performing fine motor tasks. Radiographs demonstrate advanced osteoarthritis of the DIP joint with joint space narrowing and osteophytes. What is the most reliable surgical option for this patient?

. Terminal tendon plication
. Fowler central slip tenotomy
. Spiral oblique retinacular ligament (SORL) reconstruction
. DIP joint arthroplasty
. DIP joint arthrodesis

Correct Answer & Explanation

. DIP joint arthrodesis


Explanation

In the setting of a chronic mallet deformity with established DIP joint osteoarthritis and pain, soft tissue reconstructions will fail and do not address the arthritis. DIP joint arthrodesis is the most reliable treatment for pain relief and functional positioning.

Question 552

Topic: 3. Adult Reconstruction (Hip & Knee)
A 68-year-old female undergoes a primary total hip arthroplasty for osteoarthritis. On postoperative day 2, she develops acute onset of severe hip pain and inability to bear weight. X-rays show no dislocation or periprosthetic fracture. Lab work reveals a CRP of 150 mg/L (normal <5 mg/L) and a WBC count of 18,000 cells/µL. Her temperature is 38.8°C. What is the most likely diagnosis and subsequent management?
. Aseptic loosening; revision arthroplasty.
. Hematoma formation; watchful waiting and antibiotics.
. Acute periprosthetic joint infection; urgent irrigation and debridement with component retention if stable, or one-stage exchange.
. Deep vein thrombosis; anticoagulation and close observation.
. Nerve palsy; neurological consultation.

Correct Answer & Explanation

. Acute periprosthetic joint infection; urgent irrigation and debridement with component retention if stable, or one-stage exchange.


Explanation

Correct Answer: C. The constellation of acute severe pain, inability to bear weight, systemic inflammatory response (high CRP, WBC, fever), and recent surgery is highly suggestive of acute periprosthetic joint infection (PJI). Urgent irrigation and debridement (I&D) with component retention (DAIR - Debridement, Antibiotics, and Implant Retention) is the preferred initial management for acute PJI, especially if the infection is diagnosed early (within 3-4 weeks of onset) and the components are well-fixed. If DAIR fails or components are unstable, a one-stage or two-stage exchange might be necessary. Aseptic loosening usually presents later and without acute systemic inflammatory signs. Hematoma can cause pain but usually not such a strong systemic response without infection. DVT typically presents with calf swelling and tenderness, not severe hip pain and systemic signs of infection. Nerve palsy would not explain the pain, fever, and inflammatory markers.

Question 553

Topic: Total Knee Arthroplasty (TKA)

A 55-year-old male presents with severe, bilateral knee pain, worse with activity and stair climbing. Radiographs reveal tricompartmental osteoarthritis with significant joint space narrowing, subchondral sclerosis, and osteophytes. He has failed extensive conservative management including NSAIDs, physical therapy, and intra-articular injections. His BMI is 32. He is otherwise healthy. What is the most appropriate next step in management?

. Continue with conservative management including weight loss and consider repeat injections.
. Perform bilateral unicompartmental knee arthroplasties (UKA).
. Proceed with bilateral total knee arthroplasties (TKA).
. High tibial osteotomy (HTO).
. Arthroscopic debridement and lavage.

Correct Answer & Explanation

. Proceed with bilateral total knee arthroplasties (TKA).


Explanation

Correct Answer: CGiven the severe tricompartmental osteoarthritis, failure of conservative management, and the patient's age and activity level, bilateral total knee arthroplasty (TKA) is the most appropriate next step. UKA is only suitable for isolated unicompartmental disease. HTO is typically for younger, more active patients with unicompartmental varus malalignment and good bone stock, not tricompartmental disease. Arthroscopic debridement and lavage have shown limited long-term benefits for advanced osteoarthritis. While weight loss is beneficial, it's unlikely to fully resolve symptoms in severe, end-stage osteoarthritis and should be pursued as an adjunct to TKA, not as a replacement for surgical intervention when conservative measures have failed.

Question 554

Topic: 3. Adult Reconstruction (Hip & Knee)

A 68-year-old female presents with a painful total knee arthroplasty 2 years postoperatively. Serum CRP is 15 mg/L and ESR is 35 mm/hr. Synovial fluid aspiration yields a WBC count of 3,500 cells/uL with 75% PMNs. Which of the following synovial fluid biomarkers is most specific for confirming a periprosthetic joint infection (PJI)?

. Interleukin-6
. Alpha-defensin
. C-reactive protein
. Leukocyte esterase
. Lactate dehydrogenase

Correct Answer & Explanation

. Alpha-defensin


Explanation

Alpha-defensin is a highly specific and sensitive antimicrobial peptide released by neutrophils in response to infection. It is considered a major criterion or strong adjunct in modern PJI diagnostic algorithms.

Question 555

Topic: 3. Adult Reconstruction (Hip & Knee)

A 72-year-old male falls and sustains a periprosthetic femur fracture around a cemented polished taper-slip stem placed 8 years ago. Radiographs show a spiral fracture around the tip of the stem. The stem is radiographically loose with subsidence. What is the Vancouver classification and appropriate treatment?

. Vancouver A; nonoperative management
. Vancouver B1; open reduction and internal fixation (ORIF)
. Vancouver B2; revision to a long-stem prosthesis
. Vancouver B3; revision with proximal femoral replacement
. Vancouver C; ORIF with overlapping plate

Correct Answer & Explanation

. Vancouver B2; revision to a long-stem prosthesis


Explanation

A fracture around the stem (Type B) with a loose prosthesis but adequate bone stock is a Vancouver B2 fracture. The standard of care is revision arthroplasty using a long-stem prosthesis that bypasses the fracture.

Question 556

Topic: 3. Adult Reconstruction (Hip & Knee)

A 60-year-old male with a metal-on-polyethylene total hip arthroplasty presents 5 years postoperatively with groin pain. Radiographs show no loosening. Aspiration is negative for infection. Serum cobalt levels are highly elevated, while chromium levels are only mildly elevated. What is the most likely etiology?

. Polyethylene wear
. Adverse local tissue reaction (ALTR) from the bearing surface
. Trunnionosis (mechanically assisted crevice corrosion)
. Undiagnosed low-grade periprosthetic joint infection
. Dislocation of the femoral head

Correct Answer & Explanation

. Trunnionosis (mechanically assisted crevice corrosion)


Explanation

Markedly elevated cobalt levels relative to chromium in a metal-on-polyethylene THA are classic for mechanically assisted crevice corrosion (trunnionosis) at the head-neck junction. This can lead to an adverse local tissue reaction (ALTR).

Question 557

Topic: Total Hip Arthroplasty (THA)

A 65-year-old female undergoes a primary total hip arthroplasty via a posterior approach. Six weeks later, she experiences a posterior dislocation while sitting in a low chair. Which of the following component malpositions most likely contributed to this specific type of instability?

. Excessive anteversion of the acetabular cup
. Excessive retroversion of the acetabular cup
. Excessive anteversion of the femoral stem
. Increased femoral offset
. Superior placement of the acetabular center of rotation

Correct Answer & Explanation

. Excessive retroversion of the acetabular cup


Explanation

Posterior dislocation of a THA is often associated with inadequate anteversion (i.e., retroversion) of the acetabular component or femoral stem. This causes premature impingement during hip flexion and internal rotation, levering the head out posteriorly.

Question 558

Topic: 3. Adult Reconstruction (Hip & Knee)

During a primary total knee arthroplasty, the surgeon notes poor patellar tracking with a tendency for lateral subluxation. Which of the following technical errors most commonly causes this complication?

. Internal rotation of the femoral or tibial components
. Excessive external rotation of the femoral component
. Placing the patellar button too medial on the native patella
. Oversizing the tibial component
. Undersizing the femoral component

Correct Answer & Explanation

. Internal rotation of the femoral or tibial components


Explanation

Internal rotation of either the femoral or tibial components increases the Q-angle, exacerbating lateral patellar maltracking. To optimize patellar tracking, the femoral component should be placed in slight external rotation and the patellar component placed medially.

Question 559

Topic: 3. Adult Reconstruction (Hip & Knee)

A 72-year-old female sustains a fall and presents with a periprosthetic fracture around her cemented total hip arthroplasty. Radiographs demonstrate a fracture around the stem, which is visibly loose, but the proximal femoral bone stock remains adequate. According to the Vancouver classification, what is the most appropriate surgical management?

. Open reduction and internal fixation with locking plates and cables
. Revision to a long, fully porous-coated or fluted tapered cementless stem
. Proximal femoral replacement
. Impaction bone grafting with a cemented short stem
. Isolated cerclage wiring

Correct Answer & Explanation

. Revision to a long, fully porous-coated or fluted tapered cementless stem


Explanation

This is a Vancouver B2 fracture (fracture around a loose stem with adequate bone stock). The standard of care is revision arthroplasty using a long cementless stem that bypasses the fracture by at least two cortical diameters.

Question 560

Topic: 3. Adult Reconstruction (Hip & Knee)

A 68-year-old male presents with a painful total knee arthroplasty 3 years postoperatively. Serum ESR is 45 mm/hr and CRP is 25 mg/L. Joint aspiration yields a synovial WBC count of 4,500 cells/uL with 85% polymorphonuclear neutrophils, and the alpha-defensin test is positive. According to the current consensus criteria, what is the most appropriate next step?

. Perform a second aspiration to confirm the findings
. Initiate a 6-week course of empiric intravenous antibiotics
. Schedule a 2-stage revision arthroplasty
. Perform an open debridement, antibiotics, and implant retention (DAIR)
. Proceed with a single-stage revision arthroplasty

Correct Answer & Explanation

. Schedule a 2-stage revision arthroplasty


Explanation

The patient meets definitive criteria for a chronic periprosthetic joint infection (positive alpha-defensin, elevated synovial WBC > 3000, and PMN > 80%). The gold standard treatment for chronic PJI in the United States is a two-stage revision arthroplasty.