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Question 4981

Topic: Total Hip Arthroplasty (THA)

A 68-year-old woman with a 9-year history of type II diabetes is seen 11 weeks after an uncemented left total hip replacement. When seen 6 weeks after surgery, some mild erythema and induration at the distal incision was noted, but no drainage. She states that drainage started 2 weeks ago. Examination shows turbid drainage coming from the distal third of the incision with mild surrounding erythema. Hip range of motion causes mild discomfort. Investigations reveal an erythrocyte sedimentation rate of 45 mm/h(reference range, 0-20 mm/h) and C-reactive protein of 54 mg/L (reference range, 0.08-3.1 mg/L). A rapid polymerase chain reaction of the swabbed fluid is positive for methicillin-resistant Staphylococcus aureus.Hip aspiration under fluoroscopy is attempted but no fluid is obtained. What is the most appropriate treatment?

. Debridement of the skin and superficial tissues
. Debridement and removal of the implants and insertion of an antibiotic spacer
. Debridement of superficial and deep tissues including the joint with exchange of the modular head and liner
. Prescription for sulfamethoxazole and trimethoprim (Bactrim DS), 1 tablet, twice daily for 14 days, and then re-evaluate the patient

Correct Answer & Explanation

. Debridement of the skin and superficial tissues


Explanation

This case illustrates the treatment choices to address a postsurgical deep infection at 11 weeks postsurgery.Considering the progression of symptoms and persistent drainage, one needs to assume the infection is deep. Wound drainage beginning at 9 weeks after surgery is unlikely to be the result of a superficial infection. The absence of fluid on the attempted aspiration may occur in situations in which a sinus tract allows most of the fluid to escape the joint. Injection of contrast could confirm the presence of a sinus tract. Debridement and removal of the implants and insertion of an antibiotic spacer are most appropriate because the results of a single debridement at 11 weeks with a resistant organism are poor for curing or controlling infection. The use of antibiotics alone or a superficial debridement is inadequate in this setting.

Question 4982

Topic: 3. Adult Reconstruction (Hip & Knee)

An 82-year-old female with a history of a cemented right total hip arthroplasty performed 12 years ago presents after a ground-level fall. Radiographs demonstrate a fracture around the tip of the femoral stem. The stem is radiographically loose, but there is adequate remaining femoral bone stock. According to the Vancouver classification, how should this fracture be managed?

. Open reduction internal fixation with a locking plate and cables, leaving the stem in place
. Revision total hip arthroplasty using a fully porous-coated long diaphyseal-engaging stem
. Revision total hip arthroplasty using a cemented standard-length stem
. Proximal femoral replacement (megaprosthesis)
. Nonoperative management with a spica cast

Correct Answer & Explanation

. Open reduction internal fixation with a locking plate and cables, leaving the stem in place


Explanation

This is a Vancouver B2 periprosthetic femoral fracture (fracture around the stem, loose prosthesis, adequate bone stock). The standard of care for a B2 fracture is revision of the femoral component. Because the proximal bone stock is compromised by the fracture and the loose initial stem, a longer revision stem that bypasses the fracture by at least 2 to 3 cortical diameters and achieves stable diaphyseal fixation (typically a fully porous-coated or fluted tapered stem) is required.

Question 4983

Topic: 3. Adult Reconstruction (Hip & Knee)

A 35-year-old man presents with a posterior hip dislocation and associated posterior wall acetabular fracture after a motor vehicle collision. Closed reduction is performed in the emergency department. The post-reduction CT scan reveals a 40% posterior wall defect with a significant area of marginal impaction. What is the most critical step during open reduction and internal fixation to ensure a congruent joint and minimize post-traumatic arthritis?

. Excision of the impacted articular segment to prevent avascular necrosis
. Elevation of the impacted articular segment and bone grafting of the underlying void
. Securing the posterior wall with under-contoured reconstruction plates to compress the impaction
. Fixation with spring plates without elevating the impacted segment
. Immediate total hip arthroplasty due to poor prognosis

Correct Answer & Explanation

. Excision of the impacted articular segment to prevent avascular necrosis


Explanation

Marginal impaction must be elevated to restore the articular congruity of the acetabulum. The resulting metaphyseal void must be filled with cancellous bone graft to support the articular surface. Once the articular surface is restored, the posterior wall is reduced and fixed with a buttress plate (often supplemented with spring plates if fragments are small). Failure to elevate marginal impaction leaves a defect in the joint surface, leading to rapid post-traumatic osteoarthritis.

Question 4984

Topic: 3. Adult Reconstruction (Hip & Knee)

In aseptic loosening of a total hip arthroplasty, osteolysis is primarily driven by the biological response to particulate wear debris. Which of the following cell types is the primary effector that phagocytoses the polyethylene debris and initiates the inflammatory cascade?

. Osteoblasts
. T-lymphocytes
. Polymorphonuclear neutrophils
. Macrophages
. Fibroblasts

Correct Answer & Explanation

. Osteoblasts


Explanation

Macrophages are the primary cells that recognize and phagocytose polyethylene wear debris (particularly particles 0.1 to 10 micrometers in size). Upon phagocytosis, macrophages secrete pro-inflammatory cytokines (such as TNF-alpha, IL-1, IL-6) that ultimately stimulate osteoclastic bone resorption, leading to osteolysis and aseptic loosening.

Question 4985

Topic: 3. Adult Reconstruction (Hip & Knee)

In total joint arthroplasty, particulate debris can lead to osteolysis and implant loosening. Wear that occurs between two primary bearing surfaces intended for motion (e.g., the femoral head and the polyethylene liner) is classified as which of the following?

. Mode 1
. Mode 2
. Mode 3
. Mode 4
. Mode 5

Correct Answer & Explanation

. Mode 1


Explanation

Mode 1 wear occurs between the primary bearing surfaces. Mode 2 occurs when a primary bearing rubs against a nonbearing surface, Mode 3 involves third-body wear, and Mode 4 involves two nonbearing surfaces rubbing together.

Question 4986

Topic: 3. Adult Reconstruction (Hip & Knee)
Highly cross-linked polyethylene (HXLPE) is manufactured to decrease wear rates in total hip arthroplasty components. While the irradiation process successfully increases wear resistance, which of the following material properties is most significantly decreased as a direct result?
. Yield strength
. Ultimate tensile strength
. Elastic modulus
. Fracture toughness
. Oxidation resistance

Correct Answer & Explanation

. Fracture toughness


Explanation

Irradiating polyethylene creates free radicals that form cross-links, improving wear resistance. However, this process alters the polymer chains, resulting in reduced ductility, fatigue resistance, and fracture toughness, making the material more susceptible to catastrophic failure under cyclic loading.

Question 4987

Topic: 3. Adult Reconstruction (Hip & Knee)
A patient presents with a painful total knee arthroplasty, overlying eczematous dermatitis, and aseptic loosening 1 year postoperatively. Patch testing reveals a severe systemic nickel allergy. This implant complication is mediated by which of the following immunologic mechanisms?
. IgE-mediated mast cell degranulation (Type I)
. IgG-mediated complement activation (Type II)
. Immune complex deposition (Type III)
. T-cell mediated delayed-type hypersensitivity (Type IV)
. Direct macrophage toxicity without lymphocyte involvement

Correct Answer & Explanation

. T-cell mediated delayed-type hypersensitivity (Type IV)


Explanation

Metal hypersensitivity reactions, most commonly to nickel, cobalt, or chromium, represent a Type IV delayed hypersensitivity response. It is a cell-mediated response driven by previously sensitized T-lymphocytes reacting to the metal ions acting as haptens.

Question 4988

Topic: 3. Adult Reconstruction (Hip & Knee)
In total joint arthroplasty, aseptic loosening is frequently driven by a macrophage-mediated biological response to ultra-high-molecular-weight polyethylene (UHMWPE) wear debris. Which particle size is most biologically active in inducing this osteolytic response?
. 0.1 to 1.0 micrometers
. 5.0 to 10.0 micrometers
. 10 to 50 micrometers
. 50 to 100 micrometers
. Greater than 100 micrometers

Correct Answer & Explanation

. 0.1 to 1.0 micrometers


Explanation

Macrophages preferentially phagocytose submicron-sized UHMWPE wear particles, typically between 0.1 and 1.0 micrometers. This triggers the release of pro-inflammatory cytokines (TNF-alpha, IL-1, IL-6), leading to osteoclast activation and periprosthetic osteolysis.

Question 4989

Topic: Total Hip Arthroplasty (THA)

During pre-operative templating for a primary total hip arthroplasty (THA), the surgeon decides to use a high-offset femoral stem instead of a standard-offset stem of the same neck length. What is the primary biomechanical effect of this decision?

. Increases global leg length
. Decreases the abductor moment arm
. Decreases the joint reaction force across the hip
. Increases the risk of bony impingement during abduction
. Decreases soft tissue tension in the gluteus medius

Correct Answer & Explanation

. Increases global leg length


Explanation

Increasing the femoral offset lateralizes the proximal femur, which increases the abductor moment arm. By increasing the abductor moment arm, less force is required by the abductor muscles to maintain the pelvis level during single-leg stance. This subsequently decreases the overall joint reaction force across the hip joint, reducing wear rates. It does not independently increase leg length.

Question 4990

Topic: 3. Adult Reconstruction (Hip & Knee)

During a revision total knee arthroplasty (TKA), the surgeon uses a smaller femoral component and makes up the flexion space by using a thicker polyethylene insert. What is the most likely geometric consequence of this technical decision?

. Acquired patella alta
. Elevation of the joint line leading to relative patella baja (infera)
. Decreased mid-flexion laxity
. Increased active range of motion
. Excessive tension on the posterior cruciate ligament

Correct Answer & Explanation

. Acquired patella alta


Explanation

Using a smaller femoral component increases the flexion gap. To balance this, a thicker polyethylene insert is often used. However, this elevates the joint line relative to the tibial tubercle. An elevated joint line leads to relative patella baja (infera), which can alter patellar kinematics, cause anterior knee pain, restrict range of motion, and increase the risk of patellar impingement against the tibial tray.

Question 4991

Topic: 3. Adult Reconstruction (Hip & Knee)

According to the Musculoskeletal Infection Society (MSIS) criteria for periprosthetic joint infection (PJI), which of the following is considered a definitive major criterion for diagnosing PJI?

. A single positive intraoperative tissue culture
. A sinus tract communicating with the prosthesis
. An elevated erythrocyte sedimentation rate (ESR) > 30 mm/hr
. Synovial fluid white blood cell (WBC) count of 1,500 cells/µL
. Positive alpha-defensin test

Correct Answer & Explanation

. A single positive intraoperative tissue culture


Explanation

According to the consensus MSIS criteria, the definitive major criteria for PJI are: 1) A sinus tract communicating directly with the joint space, or 2) Two positive periprosthetic cultures with phenotypically identical organisms. The other options are considered minor criteria (elevated ESR/CRP, elevated synovial WBC/PMN %, positive alpha-defensin, or a single positive culture).

Question 4992

Topic: 3. Adult Reconstruction (Hip & Knee)

A 68-year-old male presents with deep thigh pain 12 years after a cementless total hip arthroplasty. Radiographs demonstrate eccentric positioning of the femoral head within the acetabular cup and extensive periprosthetic radiolucencies.

What is the primary cellular mediator of the osteolysis demonstrated in this condition?

. T-cell mediated delayed type IV hypersensitivity
. Direct osteoblast toxicity from free metal ions
. Macrophage phagocytosis of particulate wear debris
. Complement-mediated cell lysis
. Bacterial biofilm formation releasing exotoxins

Correct Answer & Explanation

. T-cell mediated delayed type IV hypersensitivity


Explanation

The clinical scenario and radiograph describe aseptic loosening due to osteolysis, classically driven by polyethylene wear debris (particle disease). The primary mechanism is the phagocytosis of submicron (0.1 to 10 micrometers) particulate debris by macrophages. These activated macrophages release pro-inflammatory cytokines (TNF-alpha, IL-1, IL-6), which stimulate osteoclastogenesis via the RANK/RANKL pathway, leading to localized bone resorption.

Question 4993

Topic: 3. Adult Reconstruction (Hip & Knee)

A patient complains of a painful catching sensation in their knee one year after undergoing a posterior-stabilized (PS) total knee arthroplasty. The physical examination reveals an audible pop as the knee is actively extended. At what arc of motion does 'patellar clunk syndrome' most classically occur?

. During extension from 30 to 45 degrees of flexion
. At deep flexion greater than 110 degrees
. During initial flexion from 0 to 10 degrees
. During active internal rotation of the tibia at 90 degrees
. Only during passive hyperextension of the knee

Correct Answer & Explanation

. During extension from 30 to 45 degrees of flexion


Explanation

Patellar clunk syndrome is a complication classically associated with posterior-stabilized (PS) TKA designs. It is caused by the formation of a fibrosynovial nodule at the superior pole of the patella. As the knee extends from a flexed position (typically catching around 30 to 45 degrees of flexion), the nodule pops out of the intercondylar box of the femoral component, causing a painful clunk.

Question 4994

Topic: Total Hip Arthroplasty (THA)

Trunnionosis, or wear at the head-neck junction of a modular femoral stem, has become increasingly recognized in total hip arthroplasty. Which of the following implant combinations represents the highest risk factor for developing symptomatic trunnionosis?

. A 28-mm titanium head on a titanium stem
. A 32-mm ceramic head on a cobalt-chrome stem
. A 28-mm cobalt-chrome head on a cobalt-chrome stem
. A 36-mm cobalt-chrome head on a titanium stem
. A 32-mm ceramic head on a titanium stem

Correct Answer & Explanation

. A 28-mm titanium head on a titanium stem


Explanation

Trunnionosis is caused by mechanically assisted crevice corrosion (fretting and galvanic corrosion). Risk factors include dissimilar metals (galvanic corrosion), larger femoral heads (which increase the toggle and frictional torque at the trunnion), and high-offset necks. A large (e.g., 36-mm) cobalt-chrome head on a titanium stem presents both mixed metals and increased torque, maximizing the risk for trunnionosis.

Question 4995

Topic: 3. Adult Reconstruction (Hip & Knee)
During preoperative planning for a revision total hip arthroplasty, the surgeon identifies a Paprosky Type IIIB acetabular defect. Which of the following radiographic findings definitively characterizes a Type IIIB defect rather than a Type IIIA defect?
. Less than 2 cm of superior component migration with an intact teardrop
. Ischial osteolysis with an intact Kohler's line
. Superior component migration > 3 cm and disruption of Kohler's line (medial migration)
. A massive uncontained posterior wall defect with a functional superior dome
. Isolated anterior column disruption with normal superior migration

Correct Answer & Explanation

. Superior component migration > 3 cm and disruption of Kohler's line (medial migration)


Explanation

The Paprosky classification for acetabular defects guides reconstruction. Type IIIA is characterized by 10-to-noon bone loss with superior migration > 3 cm, but an intact Kohler's line (the component migrates "up and out"). Type IIIB indicates severe superior and medial bone loss, resulting in > 3 cm superior migration and disruption of Kohler's line / the teardrop (the component migrates "up and in").

Question 4996

Topic: 3. Adult Reconstruction (Hip & Knee)

A 72-year-old female sustains a fall and presents with a periprosthetic femur fracture around a cemented total hip arthroplasty placed 10 years ago. Radiographs show a fracture at the tip of the stem. The stem appears to have subsided 1 cm, and there is an intact medial calcar with good diaphyseal bone stock. Based on the Vancouver classification, what is the most appropriate definitive management?

. Open reduction and internal fixation with a locking plate and cerclage cables
. Nonoperative management in a hip spica cast
. Revision total hip arthroplasty using a long, fully porous-coated or fluted tapered bypass stem
. Revision total hip arthroplasty using proximal femoral replacement (megaprosthesis)
. Revision total hip arthroplasty utilizing cortical strut allografts alone

Correct Answer & Explanation

. Open reduction and internal fixation with a locking plate and cerclage cables


Explanation

This is a Vancouver B2 periprosthetic fracture. The fracture is around or just below the tip of the stem (Type B), the stem is loose as evidenced by subsidence (differentiating it from B1), but there is adequate remaining bone stock (differentiating it from B3). The standard of care for a Vancouver B2 fracture is revision to a long stem (fluted, tapered, or fully porous-coated) that bypasses the fracture by at least two cortical diameters.

Question 4997

Topic: 3. Adult Reconstruction (Hip & Knee)

During a primary total knee arthroplasty, the surgeon inadvertently places the femoral component in 5 degrees of internal rotation relative to the surgical transepicondylar axis. What is the expected clinical and biomechanical consequence of this malrotation?

. Medial patellar subluxation and a tight lateral flexion gap
. Lateral patellar subluxation and a tight lateral flexion gap
. Lateral patellar subluxation and a tight medial flexion gap
. Medial patellar subluxation and a tight medial extension gap
. Symmetric flexion and extension gaps with isolated anterior knee pain

Correct Answer & Explanation

. Medial patellar subluxation and a tight lateral flexion gap


Explanation

Internal rotation of the femoral component in TKA effectively moves the lateral condyle anteriorly and the medial condyle posteriorly. This has two primary effects: 1) It medially translates the trochlear groove, increasing the Q-angle and driving the patella to track laterally (lateral subluxation). 2) By taking less bone off the posterior medial condyle, it results in a tight medial flexion gap (asymmetric flexion space).

Question 4998

Topic: 3. Adult Reconstruction (Hip & Knee)

Highly cross-linked polyethylene (XLPE) has dramatically reduced the incidence of wear and osteolysis in modern total hip arthroplasty. Which step in the manufacturing process of XLPE is essential for eliminating the free radicals created during the cross-linking phase, thereby improving oxidative stability?

. Sterilization in an inert argon gas environment
. Remelting or annealing the polyethylene
. Adding a hydroxyapatite coating to the articulating surface
. Decreasing the dose of gamma irradiation to < 2.5 Mrad
. Cold-forging the polyethylene insert post-machining

Correct Answer & Explanation

. Sterilization in an inert argon gas environment


Explanation

XLPE is typically created by exposing conventional ultra-high-molecular-weight polyethylene to high doses of gamma irradiation (e.g., 5-10 Mrad). This breaks carbon-hydrogen bonds, forming free radicals that recombine to create cross-links. However, residual free radicals can cause severe oxidative degradation over time. Thermal treatment (remelting above the melting point, or annealing below the melting point) is essential to extinguish these residual free radicals and confer long-term oxidative stability. Adding Vitamin E is an alternative modern method to quench free radicals without melting.

Question 4999

Topic: 3. Adult Reconstruction (Hip & Knee)

A 78-year-old female presents for revision total knee arthroplasty due to aseptic loosening. Intraoperatively, following removal of the components and minimal debridement, the surgeon notes complete incompetence of both the Medial Collateral Ligament (MCL) and the Lateral Collateral Ligament (LCL), accompanied by a massive flexion gap. What is the most appropriate level of constraint for the new implant?

. Posterior Stabilized (PS) implant
. Cruciate Retaining (CR) implant
. Varus-Valgus Constrained (VVC) unlinked implant
. Rotating hinge (linked) implant
. Unicompartmental knee arthroplasty

Correct Answer & Explanation

. Posterior Stabilized (PS) implant


Explanation

The choice of constraint in TKA depends on collateral ligament integrity and gap balancing. A Varus-Valgus Constrained (VVC) implant relies on a tall tibial post and deep femoral box to provide coronal stability but requires at least one intact collateral ligament (preferably the MCL) and relatively balanced gaps. When there is global ligamentous incompetence (both MCL and LCL deficient) or severe uncorrectable gap mismatches (e.g., massive flexion gap), a linked rotating hinge prosthesis is indicated to prevent subluxation or dislocation.

Question 5000

Topic: 3. Adult Reconstruction (Hip & Knee)

During a primary posterior-stabilized total knee arthroplasty, trial reduction reveals that the knee is perfectly balanced and symmetric in full extension, but the joint is significantly tight symmetrically in 90 degrees of flexion. Which of the following surgical steps is the most appropriate initial maneuver to balance this knee?

. Resect an additional 2 mm of the distal femur
. Downsize the femoral component and resect more posterior femoral condyle
. Release the posterior capsule
. Increase the thickness of the tibial polyethylene insert
. Recut the proximal tibia to decrease the posterior slope

Correct Answer & Explanation

. Resect an additional 2 mm of the distal femur


Explanation

A knee that is tight in flexion but symmetric and balanced in extension requires an increase in the flexion gap without altering the extension gap. The posterior femoral condylar resection affects only the flexion gap. Downsizing the femoral component (shifting the anterior cut referencing to take more posterior bone) will open the flexion gap while leaving the distal femoral cut (and thus the extension gap) unchanged.