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Question 4201

Topic: 3. Adult Reconstruction (Hip & Knee)

A 65-year-old male with a metal-on-polyethylene total hip arthroplasty (titanium stem, cobalt-chromium head) performed 7 years ago presents with worsening groin pain. Inflammatory markers are within normal limits. MRI with metal artifact reduction sequence (MARS) shows a large, mixed solid and cystic mass adjacent to the joint. Serum cobalt levels are significantly elevated, while chromium levels are normal. What is the most likely etiology of this presentation?

. Polyethylene oxidation and secondary osteolysis
. Mechanically assisted crevice corrosion at the head-neck junction
. Low-virulence periprosthetic joint infection
. Adverse local tissue reaction due to edge loading of the bearing
. Galvanic corrosion between the acetabular shell and titanium screws

Correct Answer & Explanation

. Mechanically assisted crevice corrosion at the head-neck junction


Explanation

Elevated serum cobalt with normal chromium in a metal-on-polyethylene THA is classic for trunnionosis. This condition results from mechanically assisted crevice corrosion at the modular head-neck junction, leading to an adverse local tissue reaction.

Question 4202

Topic: 3. Adult Reconstruction (Hip & Knee)

Highly cross-linked polyethylene (HXLPE) has significantly reduced the incidence of wear-related osteolysis in total hip arthroplasty. During the manufacturing process, irradiation generates free radicals that must be extinguished to prevent in vivo oxidation. Which of the following accurately describes the biomechanical consequence of using a remelting process rather than an annealing process to eliminate these free radicals?

. It significantly decreases the oxidation resistance of the polyethylene.
. It decreases the fatigue and yield strength of the polyethylene.
. It increases the concentration of residual free radicals.
. It increases the material's susceptibility to adhesive wear.
. It has no significant effect on the crystallinity or mechanical properties.

Correct Answer & Explanation

. It decreases the fatigue and yield strength of the polyethylene.


Explanation

Remelting cross-linked polyethylene above its melting point extinguishes residual free radicals completely, improving oxidation resistance. However, this thermal treatment reduces the material's crystallinity, thereby decreasing its mechanical properties such as fatigue and yield strength.

Question 4203

Topic: 3. Adult Reconstruction (Hip & Knee)

A 40-year-old female with Crowe Type IV developmental dysplasia of the hip (DDH) is undergoing a complex total hip arthroplasty. The femoral head is completely dislocated and located superior to the true acetabulum. The surgeon plans a subtrochanteric shortening osteotomy. Which of the following nerve injuries is the primary reason for performing this osteotomy when attempting to reduce the hip into the true acetabulum?

. Superior gluteal nerve palsy
. Femoral nerve stretch injury
. Sciatic nerve stretch injury
. Obturator nerve avulsion
. Inferior gluteal nerve stretch injury

Correct Answer & Explanation

. Sciatic nerve stretch injury


Explanation

In Crowe IV hip dysplasia, the limb is chronically shortened. Lengthening the limb by more than 3-4 cm during THA places the sciatic nerve at a high risk of profound stretch injury, necessitating a femoral shortening osteotomy.

Question 4204

Topic: 3. Adult Reconstruction (Hip & Knee)

A 60-year-old male presents with persistent hip pain and erythema 4 weeks following a primary total hip arthroplasty. An aspiration of the hip is performed. Which of the following synovial fluid analysis results is most diagnostic of an acute periprosthetic joint infection in this specific timeframe?

. WBC count of 3,000 cells/uL with 60% PMNs
. WBC count of 1,500 cells/uL with 50% PMNs
. WBC count of 12,000 cells/uL with 92% PMNs
. WBC count of 8,000 cells/uL with 70% PMNs
. WBC count of 5,000 cells/uL with 40% PMNs

Correct Answer & Explanation

. WBC count of 12,000 cells/uL with 92% PMNs


Explanation

In the acute postoperative period (less than 6 weeks), the diagnostic threshold for periprosthetic joint infection is higher due to normal postoperative inflammation. A synovial WBC count greater than 10,000 cells/uL and greater than 90% polymorphonuclear neutrophils (PMNs) is highly indicative of acute PJI.

Question 4205

Topic: 3. Adult Reconstruction (Hip & Knee)

A 55-year-old male with a metal-on-polyethylene total hip arthroplasty utilizing a large 36 mm cobalt-chrome head on a titanium stem presents at 7 years postoperatively with vague groin pain. Radiographs reveal well-fixed components. A MARS MRI demonstrates a large cystic pseudotumor. What is the primary mechanism of failure?

. Aseptic loosening of the acetabular component
. Mechanically assisted crevice corrosion at the head-neck junction
. Polyethylene wear-induced osteolysis
. Type IV delayed hypersensitivity to titanium
. Impingement of the large diameter head on the acetabular rim

Correct Answer & Explanation

. Mechanically assisted crevice corrosion at the head-neck junction


Explanation

Mechanically assisted crevice corrosion at the modular head-neck junction (trunnionosis) can lead to adverse local tissue reactions (ALTR) and pseudotumor formation. This complication is particularly associated with large-diameter cobalt-chrome heads on titanium stems.

Question 4206

Topic: 3. Adult Reconstruction (Hip & Knee)

An 82-year-old female sustains a fall and presents with a periprosthetic femur fracture around a cemented total hip arthroplasty. Radiographs reveal a fracture at the level of the stem tip with evidence of cement mantle fracturing and 2 cm of stem subsidence. Proximal and distal bone stock is adequate. What is the most appropriate surgical management?

. Open reduction internal fixation with cables and a locking plate
. Revision arthroplasty using a long, diaphyseal-engaging cementless stem
. Revision arthroplasty using a standard-length cemented stem
. Cortical strut allografting alone
. Nonoperative management in a long leg cast

Correct Answer & Explanation

. Revision arthroplasty using a long, diaphyseal-engaging cementless stem


Explanation

This is a Vancouver B2 periprosthetic fracture, characterized by a loose stem in the setting of adequate bone stock. The gold standard treatment is revision arthroplasty using a long, diaphyseal-engaging cementless stem to bypass the fracture by at least two cortical diameters.

Question 4207

Topic: Total Hip Arthroplasty (THA)

A surgeon is evaluating operative variables to minimize dislocation rates after primary THA using a conventional posterior approach. Based on current orthopedic literature, which of the following surgical techniques most significantly reduces the rate of early postoperative posterior dislocation?

. Utilizing a 28 mm instead of a 32 mm femoral head
. Routine use of an elevated rim (lipped) polyethylene liner
. Meticulous capsulorrhaphy and repair of the short external rotators
. Reaming the acetabulum line-to-line
. Retaining the piriformis tendon while releasing the remaining rotators

Correct Answer & Explanation

. Meticulous capsulorrhaphy and repair of the short external rotators


Explanation

Enhanced soft tissue repair, specifically the meticulous reattachment of the posterior capsule and short external rotators to the greater trochanter, has been robustly shown to significantly reduce the risk of posterior dislocation following a posterior approach to the hip.

Question 4208

Topic: 3. Adult Reconstruction (Hip & Knee)

A 59-year-old male presents with deep thigh pain 12 years after receiving a cementless THA. Radiographs reveal progressive expansile osteolysis with extensive endosteal scalloping around the femoral stem, though the stem itself shows no subsidence and appears stable. What is the primary biologic initiator of this periprosthetic osteolysis?

. Type IV cell-mediated hypersensitivity reaction to titanium
. Phagocytosis of particulate polyethylene wear debris by local macrophages
. Endotoxin release from subclinical periprosthetic bacterial colonization
. Mechanical micromotion and fretting at the bone-implant interface
. Direct activation of osteoclasts by galvanic corrosion products

Correct Answer & Explanation

. Phagocytosis of particulate polyethylene wear debris by local macrophages


Explanation

Periprosthetic osteolysis in stable implants is primarily driven by particulate wear debris (most commonly polyethylene). Local macrophages phagocytose these particles and release proinflammatory cytokines like TNF-alpha and IL-1, leading to osteoclast activation and bone resorption.

Question 4209

Topic: 3. Adult Reconstruction (Hip & Knee)

A 52-year-old male with severe psoriatic arthritis on adalimumab (Humira) is scheduled for an elective total knee arthroplasty. According to current ACR/AAHKS guidelines, how should his biologic therapy be managed perioperatively?

. Continue through the perioperative period without interruption
. Stop 1 week before and resume immediately after surgery
. Stop 1 dosing cycle prior to surgery and schedule surgery when the next dose is due
. Stop 6 months before surgery
. Switch to oral methotrexate 4 weeks before surgery

Correct Answer & Explanation

. Stop 1 dosing cycle prior to surgery and schedule surgery when the next dose is due


Explanation

The ACR/AAHKS guidelines recommend withholding biologic agents for exactly one dosing cycle prior to elective arthroplasty to minimize infection risk. The medication can generally be resumed 14 days postoperatively once the surgical wound shows signs of appropriate healing.

Question 4210

Topic: 3. Adult Reconstruction (Hip & Knee)

Which of the following radiographic findings is most characteristic of psoriatic arthritis as opposed to rheumatoid arthritis?

. Diffuse periarticular osteopenia
. Symmetrical polyarticular joint destruction
. Severe ulnar deviation of the MCP joints
. Bone proliferation with periostitis and ankylosis
. Marginal erosions strictly sparing the DIP joints

Correct Answer & Explanation

. Bone proliferation with periostitis and ankylosis


Explanation

Psoriatic arthritis is characterized by a combination of bone destruction (osteolysis) and new bone formation (periostitis, ankylosis). It characteristically lacks the profound periarticular osteopenia typically seen in rheumatoid arthritis.

Question 4211

Topic: 3. Adult Reconstruction (Hip & Knee)

A patient with a long-standing history of psoriasis presents with severe, deforming joint destruction of the hands resulting in "telescoping" fingers. Which severe subtype of psoriatic arthritis does this clinical picture represent?

. Asymmetric oligoarthritis
. Symmetric polyarthritis
. Predominant spondylitis
. Arthritis mutilans
. Distal interphalangeal predominant

Correct Answer & Explanation

. Arthritis mutilans


Explanation

Arthritis mutilans is a severe, destructive form of psoriatic arthritis causing extensive bone resorption (osteolysis). This severe shortening leads to redundant skin folds and the classic "telescoping" phenomenon of the digits.

Question 4212

Topic: 3. Adult Reconstruction (Hip & Knee)

A 38-year-old female presents with mechanical catching and recurrent effusions in her knee. Imaging and gross pathology are shown.

What is the definitive treatment for this symptomatic primary lesion?

. Radiation therapy
. Systemic chemotherapy
. Arthroscopic or open synovectomy
. Total knee arthroplasty
. Intralesional corticosteroid injection

Correct Answer & Explanation

. Arthroscopic or open synovectomy


Explanation

The treatment of choice for symptomatic lipoma arborescens is arthroscopic or open synovectomy. Recurrence after thorough surgical excision is exceptionally rare.

Question 4213

Topic: 3. Adult Reconstruction (Hip & Knee)

A 50-year-old female with severe psoriatic arthritis is scheduled for a total knee arthroplasty (TKA). She is currently managed with secukinumab. What is the mechanism of action of this biologic agent?

. Inhibition of Tumor Necrosis Factor-alpha (TNF-alpha)
. Inhibition of Interleukin-17A (IL-17A)
. Inhibition of Interleukin-6 (IL-6)
. CD20 depletion on B cells
. Inhibition of Janus Kinase (JAK)

Correct Answer & Explanation

. Inhibition of Interleukin-17A (IL-17A)


Explanation

Secukinumab is a human monoclonal antibody that selectively targets and inhibits Interleukin-17A (IL-17A), a key cytokine involved in the pathogenesis of psoriatic arthritis.

Question 4214

Topic: 3. Adult Reconstruction (Hip & Knee)

When comparing outcomes of total joint arthroplasty in patients with psoriatic arthritis to those with primary osteoarthritis, patients with psoriatic arthritis are at an increased risk for which of the following complications?

. Aseptic loosening
. Periprosthetic joint infection (PJI)
. Periprosthetic fracture
. Heterotopic ossification
. Implant breakage

Correct Answer & Explanation

. Periprosthetic joint infection (PJI)


Explanation

Patients with psoriatic arthritis have a higher risk of periprosthetic joint infection following total joint arthroplasty compared to osteoarthritis patients. This is likely due to systemic immunosuppressive medications and skin flora colonizing psoriatic plaques.

Question 4215

Topic: 3. Adult Reconstruction (Hip & Knee)

A 38-year-old male presents with characteristic 'pencil-in-cup' deformities on hand radiographs. Which pathophysiologic process best explains this radiographic appearance in psoriatic arthritis?

. Isolated osteophyte formation
. Subchondral sclerosis with cyst formation
. Central articular erosions with marginal osteosclerosis
. Marginal erosions combined with periarticular bone proliferation
. Chondrocalcinosis of the articular cartilage

Correct Answer & Explanation

. Marginal erosions combined with periarticular bone proliferation


Explanation

The 'pencil-in-cup' deformity is formed by concurrent periarticular marginal erosions (osteolysis) and new bone proliferation at the entheses. This concurrent destruction and formation is classic for psoriatic arthritis.

Question 4216

Topic: 3. Adult Reconstruction (Hip & Knee)

A 52-year-old female diagnosed with Lipoma Arborescens of the suprapatellar pouch continues to have mechanical symptoms and massive effusions despite intra-articular corticosteroid injections. What is the recommended treatment?

. Radiation therapy
. Arthroscopic or open complete synovectomy
. Total knee arthroplasty
. Systemic chemotherapy
. Radioisotope synoviorthesis

Correct Answer & Explanation

. Arthroscopic or open complete synovectomy


Explanation

The treatment of choice for symptomatic lipoma arborescens that fails conservative management is arthroscopic or open synovectomy. This typically yields excellent results with a low recurrence rate.

Question 4217

Topic: 3. Adult Reconstruction (Hip & Knee)

A 52-year-old male with psoriatic arthritis is scheduled for a total hip arthroplasty. He is currently well-controlled on adalimumab (a TNF-alpha inhibitor). According to current ACR/AAHKS guidelines, what is the most appropriate perioperative management of his biologic medication?

. Continue adalimumab through the perioperative period
. Withhold adalimumab for one dosing cycle prior to surgery and restart after wound healing
. Discontinue adalimumab 6 months prior to surgery
. Switch to methotrexate 2 weeks prior to surgery
. Administer a stress dose of corticosteroids intraoperatively

Correct Answer & Explanation

. Withhold adalimumab for one dosing cycle prior to surgery and restart after wound healing


Explanation

Current ACR/AAHKS guidelines recommend withholding biologic therapies, such as adalimumab, for one dosing cycle prior to elective arthroplasty to minimize infection risk. It can be restarted once the surgical wound is fully healed (typically 14 days).

Question 4218

Topic: 3. Adult Reconstruction (Hip & Knee)

Compared to patients with primary osteoarthritis, patients with psoriatic arthritis undergoing primary total knee arthroplasty have a significantly higher risk of which of the following postoperative complications?

. Aseptic loosening
. Periprosthetic fracture
. Periprosthetic joint infection
. Heterotopic ossification
. Patellar clunk syndrome

Correct Answer & Explanation

. Periprosthetic joint infection


Explanation

Patients with psoriatic arthritis have an elevated risk of periprosthetic joint infection following arthroplasty. This is attributed to compromised skin integrity (psoriatic plaques), systemic immune dysregulation, and the use of immunomodulatory medications.

Question 4219

Topic: 3. Adult Reconstruction (Hip & Knee)

When planning total knee arthroplasty for a patient with advanced psoriatic arthritis, the surgeon must counsel the patient on which of the following elevated post-operative risks compared to primary osteoarthritis?

. Higher risk of aseptic loosening
. Higher risk of heterotopic ossification
. Higher risk of post-operative stiffness and infection
. Lower risk of venous thromboembolism
. Higher risk of periprosthetic fracture

Correct Answer & Explanation

. Higher risk of post-operative stiffness and infection


Explanation

Patients with psoriatic arthritis undergoing total joint arthroplasty have an increased risk of post-operative stiffness and infection. Skin flora alterations and immunosuppressive medications contribute to the elevated infection risk.

Question 4220

Topic: 3. Adult Reconstruction (Hip & Knee)

A 50-year-old male presents with a painless, slowly enlarging, boggy swelling of the left knee. MRI demonstrates a frond-like synovial mass with signal intensity identical to subcutaneous fat on all sequences.

What is the best initial definitive surgical treatment for a highly symptomatic patient?

. Radiotherapy
. Arthroscopic or open synovectomy
. Total knee arthroplasty
. Chemotherapy
. Corticosteroid injection alone

Correct Answer & Explanation

. Arthroscopic or open synovectomy


Explanation

The clinical and MRI findings represent lipoma arborescens, characterized by villous lipomatous proliferation of the synovium. The definitive treatment for symptomatic cases is complete open or arthroscopic synovectomy.