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Question 6281

Topic: 3. Adult Reconstruction (Hip & Knee)

A 65-year-old male with a 5-year history of a primary total hip arthroplasty presents with 4 days of acute severe hip pain, fevers, and chills following a dental extraction. Radiographs show well-fixed implants without lucencies. Aspiration yields 65,000 WBC/uL with 95% neutrophils. What is the most appropriate initial surgical management?

. One-stage exchange arthroplasty
. Two-stage exchange arthroplasty with an articulating antibiotic spacer
. Debridement, antibiotics, and implant retention (DAIR) with modular component exchange
. Suppressive chronic oral antibiotic therapy
. Resection arthroplasty (Girdlestone procedure)

Correct Answer & Explanation

. Debridement, antibiotics, and implant retention (DAIR) with modular component exchange


Explanation

This patient has an acute hematogenous periprosthetic joint infection (symptoms < 3 weeks) with well-fixed implants. The standard of care in this scenario is a thorough irrigation, debridement, antibiotics, and implant retention (DAIR) along with the exchange of modular components (femoral head and polyethylene liner).

Question 6282

Topic: 3. Adult Reconstruction (Hip & Knee)

A 70-year-old female complains of persistent pain 2 years following a total knee arthroplasty. Aspiration yields synovial fluid with 2,500 WBC/uL and 75% PMNs. Serum CRP is 12 mg/L. Which of the following synovial fluid biomarkers offers the highest specificity for confirming a chronic periprosthetic joint infection?

. Synovial fluid leukocyte esterase
. Synovial fluid C-reactive protein (CRP)
. Synovial fluid Interleukin-6 (IL-6)
. Synovial fluid Alpha-defensin
. Synovial fluid D-dimer

Correct Answer & Explanation

. Synovial fluid Alpha-defensin


Explanation

Alpha-defensin is an antimicrobial peptide released by neutrophils in response to pathogens. It is highly specific (approaching 95-100%) for diagnosing periprosthetic joint infection, making it an excellent confirmatory biomarker in indeterminate cases.

Question 6283

Topic: 3. Adult Reconstruction (Hip & Knee)

During the workup of a painful total knee arthroplasty, a synovial fluid sample is sent for alpha-defensin testing. What specific cellular process does the presence of alpha-defensin primarily reflect in the context of periprosthetic joint infection (PJI)?

. Macrophage phagocytosis of wear debris
. T-cell mediated delayed hypersensitivity to metal
. Neutrophil activation in response to pathogens
. Fibroblast proliferation in the periprosthetic membrane
. Osteoblast suppression by bacterial biofilms

Correct Answer & Explanation

. Neutrophil activation in response to pathogens


Explanation

Alpha-defensin is an antimicrobial peptide released specifically by activated neutrophils in response to infection. It serves as a highly sensitive and specific synovial fluid biomarker for diagnosing PJI.

Question 6284

Topic: 3. Adult Reconstruction (Hip & Knee)

A 68-year-old female presents with an acutely painful total hip arthroplasty 14 days post-operatively. Her vitals are stable, but the wound is actively draining purulent fluid. Radiographs show well-fixed components. According to current guidelines, what is the most critical indication that supports a Debridement, Antibiotics, and Implant Retention (DAIR) procedure over a 2-stage revision?

. Symptoms present for greater than 4 weeks.
. The presence of a methicillin-resistant Staphylococcus aureus (MRSA) infection.
. A symptom duration of less than 3 to 4 weeks with stable components.
. A culture-negative infection profile on preliminary joint aspirate.
. The inability to safely exchange the modular polyethylene liner.

Correct Answer & Explanation

. A symptom duration of less than 3 to 4 weeks with stable components.


Explanation

DAIR is generally indicated for acute post-operative infections (within 3-4 weeks of surgery) or acute hematogenous infections. A prerequisite for success is having well-fixed components and a healthy soft-tissue envelope capable of being closed.

Question 6285

Topic: 3. Adult Reconstruction (Hip & Knee)

During a revision total hip arthroplasty for a suspected chronic periprosthetic joint infection, the removed components undergo sonication in the microbiology lab. What is the primary purpose of utilizing sonication in this scenario?

. To sterilize the implant for potential immediate reimplantation.
. To mechanically dislodge the bacterial biofilm and improve culture yield.
. To differentiate between metal hypersensitivity and bacterial infection.
. To accurately measure the strength of the previous bone-implant interface.
. To neutralize local antibiotic resistance genes prior to culturing.

Correct Answer & Explanation

. To mechanically dislodge the bacterial biofilm and improve culture yield.


Explanation

Sonication involves applying low-frequency ultrasound waves to explanted hardware in a fluid medium. This mechanically disrupts and dislodges bacteria embedded in the biofilm, significantly improving the sensitivity and yield of microbiological cultures in PJI.

Question 6286

Topic: 3. Adult Reconstruction (Hip & Knee)

A 65-year-old male presents with acute onset of severe right knee pain, swelling, and erythema 2 weeks after an uncomplicated primary total knee arthroplasty (TKA). Joint aspiration yields 45,000 WBC/uL with 92% neutrophils, and the implant appears well-fixed on radiographs. What is the most appropriate initial surgical management?

. One-stage revision arthroplasty
. Two-stage revision arthroplasty with an articulating antibiotic spacer
. Debridement, antibiotics, and implant retention (DAIR) with modular component exchange
. Intravenous antibiotics for 6 weeks followed by chronic oral suppression
. Suppressive oral antibiotics without surgical intervention

Correct Answer & Explanation

. Debridement, antibiotics, and implant retention (DAIR) with modular component exchange


Explanation

For acute early postoperative periprosthetic joint infection (PJI) within 4 weeks of the index surgery, the standard of care is Debridement, Antibiotics, and Implant Retention (DAIR) alongside modular polyethylene liner exchange. This strategy yields high success rates provided the implants are well-fixed and soft tissues are viable.

Question 6287

Topic: 3. Adult Reconstruction (Hip & Knee)

A 68-year-old man who underwent a total knee arthroplasty 2 years ago presents with new-onset knee pain. Aspiration of the knee yields synovial fluid. Which of the following synovial fluid analysis results is most predictive of the absence of a prosthetic joint infection?

. WBC count of 5,000/mm3 with 75% neutrophils
. WBC count of 3,500/mm3 with 65% neutrophils
. WBC count of 1,500/mm3 with 45% neutrophils
. WBC count of 10,000/mm3 with 85% neutrophils
. WBC count of 2,000/mm3 with 80% neutrophils

Correct Answer & Explanation

. WBC count of 1,500/mm3 with 45% neutrophils


Explanation

Correct Answer: CSynovial fluid analysis is highly sensitive for detecting infection in total knee arthroplasties. Studies have shown that an absolute leukocyte count of less than 1,700 to 2,500/mm3 and a differential of less than 50% to 60% neutrophils are accurate predictors of the absence of infection. Therefore, a WBC count of 1,500/mm3 with 45% neutrophils makes a prosthetic joint infection highly unlikely.

Question 6288

Topic: 3. Adult Reconstruction (Hip & Knee)

During the tibial bone resection in a total knee arthroplasty, the surgeon must be mindful of the common peroneal nerve. At the level of the tibial resection, the common peroneal nerve is anatomically protected by lying superficial to which of the following structures?

. Popliteus muscle belly
. Lateral head of the gastrocnemius
. Biceps femoris tendon
. Arcuate ligament
. Soleus muscle

Correct Answer & Explanation

. Lateral head of the gastrocnemius


Explanation

Correct Answer: BAt the level of the tibial bone resection in total knee arthroplasty, the common peroneal nerve lies superficial to the lateral head of the gastrocnemius muscle, which provides a layer of protection. The mean distance from the bony posterolateral corner of the tibia to the nerve is approximately 1.5 cm, and this distance is greater in larger legs.

Question 6289

Topic: 3. Adult Reconstruction (Hip & Knee)

During the tibial bone resection in a total knee arthroplasty, the common peroneal nerve is at risk of injury. At this specific level, which of the following structures lies directly deep to the common peroneal nerve, thereby offering it some protection?

. Popliteus muscle belly
. Biceps femoris tendon
. Lateral head of the gastrocnemius
. Arcuate ligament
. Soleus muscle

Correct Answer & Explanation

. Arcuate ligament


Explanation

Correct Answer: CAt the level of the tibial bone cut in a total knee arthroplasty, the common peroneal nerve lies superficial to the lateral head of the gastrocnemius muscle. This muscle belly provides a protective buffer between the nerve and the posterior aspect of the proximal tibia, reducing the risk of iatrogenic injury during bone resection.

Question 6290

Topic: 3. Adult Reconstruction (Hip & Knee)

A 55-year-old man undergoes an uncomplicated primary total hip arthroplasty. Three years later, he presents complaining of a high-pitched "squeaking" sound from his hip during certain movements. Which bearing surface combination was most likely utilized?

. Metal-on-polyethylene
. Ceramic-on-polyethylene
. Metal-on-metal
. Ceramic-on-ceramic
. Oxinium-on-polyethylene

Correct Answer & Explanation

. Ceramic-on-ceramic


Explanation

Squeaking is a well-documented, specific complication associated with ceramic-on-ceramic bearing surfaces in total hip arthroplasty. It is multifactorial but often related to edge loading, microseparation, or component malposition.

Question 6291

Topic: 3. Adult Reconstruction (Hip & Knee)

A 65-year-old woman presents with painful catching and a palpable 'clunk' in her knee when extending from a flexed position, one year after a posterior-stabilized total knee arthroplasty. Where is the fibrotic nodule responsible for this condition typically located?

. Inferior pole of the patella
. Superior pole of the patella / quadriceps tendon junction
. Medial patellofemoral ligament
. Anterior aspect of the tibial polyethylene post
. Lateral retinaculum

Correct Answer & Explanation

. Superior pole of the patella / quadriceps tendon junction


Explanation

Patellar clunk syndrome is characterized by a fibrotic nodule forming at the superior pole of the patella or distal quadriceps tendon. During extension, this nodule catches in the intercondylar box of a posterior-stabilized femoral component.

Question 6292

Topic: 3. Adult Reconstruction (Hip & Knee)

Aseptic loosening is the most common mode of failure in total joint arthroplasty and is primarily driven by an inflammatory response to particulate wear debris. Which cell type is the primary effector of the subsequent osteolysis?

. Fibroblasts
. Polymorphonuclear neutrophils
. T-lymphocytes
. Macrophages
. Plasma cells

Correct Answer & Explanation

. Macrophages


Explanation

Macrophages are the primary effector cells in periprosthetic osteolysis. They phagocytose the particulate wear debris (commonly polyethylene) and release pro-inflammatory cytokines (such as TNF-alpha, IL-1, and IL-6), which ultimately stimulate osteoclast-mediated bone resorption.

Question 6293

Topic: 3. Adult Reconstruction (Hip & Knee)

A 55-year-old woman with a history of a metal-on-metal total hip arthroplasty 10 years ago presents with groin pain and a palpable mass. Serum cobalt and chromium levels are significantly elevated. MRI with MARS shows a large cystic mass communicating with the joint. What is the predominant histologic finding expected in the periprosthetic tissue?

. Abundant polymorphonuclear leukocytes with fibrin deposition
. Extensive perivascular lymphocytic infiltrate and tissue necrosis
. Sheets of lipid-laden foamy macrophages
. Giant cells with polarizable birefringent particles
. Malignant spindle cells with a high mitotic index

Correct Answer & Explanation

. Extensive perivascular lymphocytic infiltrate and tissue necrosis


Explanation

Adverse local tissue reaction (ALTR) or ALVAL associated with metal-on-metal hip implants is a Type IV delayed hypersensitivity response. It is histologically characterized by an extensive perivascular lymphocytic infiltrate and areas of extensive tissue necrosis.

Question 6294

Topic: 3. Adult Reconstruction (Hip & Knee)

A 68-year-old female experiences her third posterior dislocation following a primary total hip arthroplasty. CT evaluation demonstrates the acetabular component is placed in 35 degrees of inclination and 5 degrees of anteversion. The femoral stem is in 15 degrees of anteversion. What is the most appropriate surgical intervention?

. Revision of the femoral stem to increase anteversion
. Revision of the acetabular component to increase anteversion
. Exchange to a constrained polyethylene liner
. Soft tissue repair of the posterior capsule
. Advancement of the greater trochanter

Correct Answer & Explanation

. Revision of the acetabular component to increase anteversion


Explanation

The acetabular component is under-anteverted (normal target is approximately 15-20 degrees). Revision of the acetabular cup to increase anteversion addresses the specific mechanical cause of the recurrent posterior instability.

Question 6295

Topic: 3. Adult Reconstruction (Hip & Knee)

A 65-year-old female is 3 weeks post-operative from a primary total knee arthroplasty (TKA). She reports a sudden pop and is now unable to perform a straight leg raise. Examination reveals a high-riding patella and a palpable defect at the tibial tubercle. Direct repair is attempted but the tissue is highly friable. What is the best salvage option?

. Casting in extension for 6 weeks
. Patellectomy
. Extensor mechanism reconstruction with an allograft
. Revision to a hinged total knee arthroplasty
. Hamstring autograft transfer

Correct Answer & Explanation

. Extensor mechanism reconstruction with an allograft


Explanation

Extensor mechanism disruption post-TKA is a devastating complication. Because direct repair usually fails due to poor tissue quality, reconstruction with an extensor mechanism allograft or synthetic mesh is indicated.

Question 6296

Topic: 3. Adult Reconstruction (Hip & Knee)
In total hip arthroplasty, the generation of ultra-high-molecular-weight polyethylene (UHMWPE) wear debris leads to aseptic loosening. Which of the following best describes the cellular mechanism responsible for osteolysis?
. Osteoblast phagocytosis leading to decreased bone formation
. Direct mechanical abrasion of the bone by polyethylene particles
. Lymphocyte-mediated type IV hypersensitivity reaction
. Macrophage phagocytosis resulting in the release of TNF-alpha and RANKL
. Neutrophil activation leading to excessive reactive oxygen species production

Correct Answer & Explanation

. Macrophage phagocytosis resulting in the release of TNF-alpha and RANKL


Explanation

Macrophage phagocytosis of submicron polyethylene wear particles triggers a pro-inflammatory cascade (releasing TNF-alpha, IL-1, and IL-6), which subsequently upregulates RANKL expression, driving osteoclastogenesis and periprosthetic osteolysis.

Question 6297

Topic: 3. Adult Reconstruction (Hip & Knee)

A 70-year-old woman experiences recurrent posterior dislocations following a posterior approach total hip arthroplasty. Imaging shows the acetabular cup at 45 degrees of abduction and 20 degrees of anteversion, and the stem at 15 degrees of anteversion. The abductor mechanism is intact. What is the most appropriate surgical intervention?

. Revise the acetabular cup to 60 degrees of abduction
. Revise the femoral stem to 0 degrees of anteversion
. Perform a trochanteric advancement
. Exchange to a dual mobility or constrained liner construct
. Convert to an excision arthroplasty (Girdlestone procedure)

Correct Answer & Explanation

. Exchange to a dual mobility or constrained liner construct


Explanation

The components are placed in acceptable alignment (safe zone). In a patient with recurrent instability, intact abductors, and properly positioned components, revision to a dual mobility or constrained liner is the most appropriate treatment to restore stability.

Question 6298

Topic: 3. Adult Reconstruction (Hip & Knee)

A 65-year-old man presents 3 weeks after a primary total knee arthroplasty with sudden onset severe pain, swelling, and erythema of the knee. Joint aspiration yields 65,000 WBC/hpf with 92% PMNs. What is the most appropriate surgical management?

. Arthroscopic joint lavage and 6 weeks of IV antibiotics
. Single-stage revision arthroplasty
. Two-stage revision arthroplasty with an antibiotic spacer
. Debridement, antibiotics, and implant retention (DAIR) with modular polyethylene exchange
. Above-knee amputation

Correct Answer & Explanation

. Debridement, antibiotics, and implant retention (DAIR) with modular polyethylene exchange


Explanation

Acute periprosthetic joint infections occurring within 4 weeks of the index surgery are best managed with Debridement, Antibiotics, and Implant Retention (DAIR), which crucially includes the exchange of modular components (polyethylene insert).

Question 6299

Topic: 3. Adult Reconstruction (Hip & Knee)

The use of highly cross-linked polyethylene (HXLPE) in total hip arthroplasty significantly reduces volumetric wear. Which specific mechanism is primarily responsible for this reduction in wear?

. Increasing the overall crystalline structure of the polymer
. Decreasing free radicals through the remelting process
. Forming carbon-carbon bonds between adjacent polymer chains
. Increasing the oxidation index of the material
. Reducing the molecular weight of the polyethylene

Correct Answer & Explanation

. Forming carbon-carbon bonds between adjacent polymer chains


Explanation

Irradiation of polyethylene strips hydrogen atoms, allowing the formation of carbon-carbon cross-links between adjacent polymer chains. This dense cross-linking network is the primary mechanism that substantially reduces adhesive and abrasive wear.

Question 6300

Topic: 3. Adult Reconstruction (Hip & Knee)

A 65-year-old man presents with acute onset of knee pain, swelling, and erythema 3 weeks after a primary total knee arthroplasty. Aspiration yields synovial fluid with 45,000 WBC/mcL and 92% polymorphonuclear neutrophils. Which of the following is the most appropriate initial surgical management?

. Suppressive intravenous antibiotics for 6 weeks without surgical intervention
. One-stage exchange arthroplasty
. Two-stage exchange arthroplasty with an articulating antibiotic spacer
. Debridement, antibiotics, and implant retention (DAIR) with polyethylene exchange
. Arthroscopic irrigation and debridement without polyethylene exchange

Correct Answer & Explanation

. Debridement, antibiotics, and implant retention (DAIR) with polyethylene exchange


Explanation

This patient has an acute post-operative periprosthetic joint infection (occurring within 4 weeks of the index procedure). Debridement, antibiotics, and implant retention (DAIR) with modular polyethylene exchange is the standard of care for acute postoperative PJI.