10. Pathology and Oncology MCQs

..Figures 112a and 112b are the anteroposterior and lateral radiographs of a 65-year-old man who has a significant history of tobacco abuse and a 6-week history of right thigh pain. Axial and sagittal MRI scans are seen in Figures 112c and 112d. His MR angiogram is shown in Figure 112e. A biopsy of a lesion is shown in Figure 112f. What is the most likely diagnosis?

A 51-year-old woman has had progressively increasing right knee pain for the past 6 months. She has a history of metastatic renal cell carcinoma to the lung and the skeletal system. Radiographs are seen in Figures 18a and 18b. The next step in management of the right distal femur lesion should consist of

An otherwise healthy 75-year-old man has a painful mass in the popliteal fossa of his right knee. A lateral radiograph of the knee, a CT scan of the distal femur, and a histopathologic specimen are shown in Figures 13a through 13c. Management should consist of

..A 60-year-old woman has a proximal femur fracture. A permeative, lytic defect is recognized at the fracture site. Appropriate imaging studies are performed and show no other lesions. What is the next treatment step?

A 54-year-old woman reports worsening pain in her buttock, especially when sitting for long periods of time. She has occasional pain and paresthesias radiating down her posterior leg. She has no significant medical history. MRI scans are shown in Figures 15a and 15b and a biopsy specimen is shown in Figure 15c. What is the most likely diagnosis?

A 31-year-old woman has increasing pain and tightness in her right knee, with occasional stiffness and recurrent hemorrhagic effusions. MRI scans are shown in Figures 2a and 2b. What is the most likely diagnosis?

A 70-year-old former baseball catcher reports long-standing pain in the ring and little fingers. A gradient-echo MRI scan is shown in Figure 26. What is the most likely diagnosis?

Figures 34a through 34c show an axial proton density (spin echo long TR, short TE) image, a sagittal inversion recovery (STIR) image, and a sagittal T1-weighted (short TR, short TE) image of the left thigh. What is the most likely diagnosis?

A 56-year-old man has upper thoracic pain after undergoing stereotactic radiosurgery for a blastic metastatic lesion in the vertebral body of T5. He has normal alignment without collapse, but the tumor involves the entire vertebral body. Which factor increases this patient's risk for a pathologic fracture?

A 16-year-old boy has had left knee pain and swelling after sustaining a minor twisting injury while playing basketball 2 weeks ago. Figures 5a through 5e show the radiograph, MRI scans, and biopsy specimens. What is the most likely diagnosis?

A 21-year-old man has mild but persistent aching pain in his left proximal thigh during impact loading activities. He denies pain at rest and has no other symptoms. Figures 34a through 34e show the radiographs and T1-weighted, T2-weighted, and gadolinium MRI scans of the left hip. What is the most likely diagnosis?

Which of the following benign bone lesions can develop lung metastases?

Serum parathyroid hormone level
The plain radiograph of the shoulder shows lytic lesions in the scapular spine, distal clavicle, and the proximal third of the clavicle. There is an elliptical erosion in the proximal clavicle. These three lesions suggest a diagnosis of metastatic bone disease or multiple myeloma. The biopsy specimen shows plasma cells. The plasma cells have these characteristic features:
Eccentrically placed nucleus
Peripheral clumping of the nuclear chromatin A perinuclear halo
The diagnosis is multiple myeloma. Staging is important and is performed with a skeletal survey, bone marrow biopsy, hemoglobin level, and chemistry studies including kidney function and serum calcium determination.
Serum protein electrophoresis is performed to assess the amount of abnormal gammaglobulin in the serum. There are three major criteria in the diagnosis of multiple myeloma:

Examination of the shoulder seen in Figure 52 shows atrophy and tenderness of the infraspinous fossa and profound weakness in external rotation. The supraspinous fossa shows normal muscle bulk. What is the most likely cause of this condition?

Figure 2 shows the radiograph of a 72-year-old woman who reports pain after a fall. History includes several years of increasing thigh pain and limb shortening. Management consisting of an extensive work-up for infection reveals normal laboratory studies, a positive bone scan, and a negative hip aspiration. What is the most likely etiology of this complication?

A 13-year-old girl has had increasing left hip pain for the past 4 months. A radiograph, bone scan, MRI scan, and photomicrograph are shown in Figures 1a through 1d. Which of the following immunohistochemistry results would confirm the most likely diagnosis?

A 30-year-old patient has wrist pain. A radiograph and biopsy specimen are shown in Figures 34a and 34b. What is the most likely diagnosis?

Figure 26 shows the radiograph of a 48-year-old woman who has right arm pain and hematuria. A bone scan reveals increased uptake in the left ribs and thoracic spine. A needle biopsy specimen shows that the lesion is highly keratin positive and composed primarily of clear cells. What is the best course of action?

A 21-year-old man has had right groin pain for the past year. A radiograph, CT scan, MRI scans, and a biopsy specimen are shown in Figures 50a through 50e. What is the most likely diagnosis?

What clinical finding is associated with the least favorable prognosis in an adolescent patient who has been diagnosed with a high-grade osteosarcoma of the distal femur?