Question 10121
Topic: Biology, Genetics & Bone HealingA 65-year-old female on long-term alendronate therapy for osteoporosis presents with atraumatic thigh pain. Radiographs demonstrate focal lateral cortical thickening of the subtrochanteric femur with a transverse radiolucent line. Which of the following is the primary pathophysiologic mechanism leading to this atypical femur fracture (AFF)?
Correct Answer & Explanation
. Severe suppression of targeted osteoclastic bone remodeling leading to accumulation of microdamage



