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Question 161

Topic: Physiology & Rehabilitation

During the swing phase of the human gait cycle, the knee joint experiences relatively low compressive loads and high sliding speeds. Which mechanism of articular cartilage lubrication predominates under these conditions?

. Boundary lubrication
. Squeeze-film lubrication
. Elastohydrodynamic (fluid-film) lubrication
. Weeping lubrication
. Boosted lubrication

Correct Answer & Explanation

. Boundary lubrication


Explanation

Elastohydrodynamic (fluid-film) lubrication predominates when joint loads are low and sliding speeds are high. In contrast, boundary lubrication, mediated by lubricin, predominates at low speeds and high loads (e.g., stance phase).

Question 162

Topic: Physiology & Rehabilitation

During a direct lateral (Hardinge) approach to the hip, proximal splitting of the gluteus medius must be limited to prevent denervation of its anterior portion and the tensor fasciae latae. What is the generally accepted maximal safe distance for this split proximal to the tip of the greater trochanter?

. 2 cm
. 5 cm
. 8 cm
. 11 cm
. 14 cm

Correct Answer & Explanation

. 5 cm


Explanation

The superior gluteal nerve lies approximately 3 to 5 cm proximal to the tip of the greater trochanter. Extending the gluteus medius split beyond 5 cm risks injuring the nerve, leading to abductor weakness and Trendelenburg gait.

Question 163

Topic: Physiology & Rehabilitation

A 45-year-old weightlifter feels a sudden tear in his chest while performing a heavy bench press. Examination reveals loss of the anterior axillary fold and weakness with internal rotation. The ruptured tendon typically inserts into which of the following anatomic locations?

. Medial lip of the bicipital groove
. Lateral lip of the bicipital groove
. Coracoid process
. Lesser tuberosity
. Greater tuberosity

Correct Answer & Explanation

. Lateral lip of the bicipital groove


Explanation

The pectoralis major tendon inserts onto the lateral lip of the bicipital groove. Ruptures typically occur at the musculotendinous junction or tendinous insertion during eccentric contraction, such as the lowering phase of a bench press.

Question 164

Topic: Physiology & Rehabilitation

A 30-year-old competitive powerlifter feels a sharp pop in his chest while attempting a heavy bench press. Exam reveals loss of the anterior axillary fold and weakness in internal rotation.

Where does the pectoralis major most commonly rupture in this scenario?

. Clavicular head origin
. Sternal head origin
. Muscle belly
. Tendinous insertion onto the humerus
. Coracoid process attachment

Correct Answer & Explanation

. Tendinous insertion onto the humerus


Explanation

Pectoralis major ruptures most commonly occur at the tendinous insertion onto the proximal humerus, predominantly involving the sternocostal head. These injuries are typically seen during eccentric contraction, such as the eccentric phase of a bench press.

Question 165

Topic: Physiology & Rehabilitation

A 30-year-old competitive weightlifter sustains an acute pectoralis major tear while bench pressing. Examination reveals loss of the anterior axillary fold. Where do these ruptures most commonly occur?

. Sternal head origin
. Clavicular head origin
. Mid-substance of the muscle belly
. Tendon insertion at the humerus
. Coracoid process attachment

Correct Answer & Explanation

. Tendon insertion at the humerus


Explanation

Pectoralis major ruptures almost exclusively occur at the distal musculotendinous junction or the tendon insertion onto the proximal humerus during maximal eccentric contraction.

Question 166

Topic: Physiology & Rehabilitation

Skeletal muscle biopsy of the gastrocnemius in an elite marathon runner reveals a heavy predominance of Type I muscle fibers. Which of the following best characterizes the physiological properties of these fibers?

. High glycogen content and fast twitch
. Anaerobic metabolism and high force production
. High mitochondria density and slow twitch
. Low myoglobin content and fast fatigue
. Large diameter and low capillary density

Correct Answer & Explanation

. High glycogen content and fast twitch


Explanation

Type I muscle fibers are slow-twitch, highly fatigue-resistant fibers that rely heavily on oxidative metabolism for sustained endurance. They are characterized by a high density of mitochondria, rich myoglobin content, and a dense capillary network.

Question 167

Topic: Physiology & Rehabilitation

Because mature articular cartilage is avascular and hypoxic, chondrocytes must rely predominantly on which metabolic pathway for their cellular energy (ATP) production?

. Oxidative phosphorylation
. Beta-oxidation of fatty acids
. Anaerobic glycolysis
. Gluconeogenesis
. Pentose phosphate pathway

Correct Answer & Explanation

. Oxidative phosphorylation


Explanation

Due to the avascular nature of mature articular cartilage, chondrocytes reside in a hypoxic environment and rely almost entirely on anaerobic glycolysis for ATP synthesis, a process regulated by hypoxia-inducible factor 1-alpha (HIF-1 alpha).

Question 168

Topic: Physiology & Rehabilitation

Due to the avascular nature of normal articular cartilage, mature chondrocytes reside in a relatively hypoxic environment. They generate ATP required for extracellular matrix synthesis primarily through:

. Oxidative phosphorylation
. Anaerobic glycolysis
. Fatty acid beta-oxidation
. The pentose phosphate pathway
. Ketone body utilization

Correct Answer & Explanation

. Oxidative phosphorylation


Explanation

Chondrocytes are adapted to a low-oxygen environment (hypoxia) and generate approximately 95% of their ATP via anaerobic glycolysis, even when oxygen is present. This is a critical adaptation for survival in avascular cartilage.

Question 169

Topic: Physiology & Rehabilitation

Adult articular chondrocytes exist in an avascular environment. Which of the following pathways is their primary source of energy production?

. Oxidative phosphorylation
. Fatty acid oxidation
. Anaerobic glycolysis
. Gluconeogenesis
. Pentose phosphate pathway

Correct Answer & Explanation

. Oxidative phosphorylation


Explanation

Due to the avascular and hypoxic nature of articular cartilage, chondrocytes rely primarily on anaerobic glycolysis for ATP production. They express high levels of hypoxia-inducible factor 1-alpha (HIF-1a) to survive.

Question 170

Topic: Physiology & Rehabilitation

During the normal gait cycle, articular cartilage relies on different lubrication mechanisms. At the initiation of movement under high loads and low speeds, which lubrication mechanism predominates?

. Elastohydrodynamic lubrication
. Squeeze-film lubrication
. Boundary lubrication
. Weeping lubrication
. Hydrodynamic lubrication

Correct Answer & Explanation

. Elastohydrodynamic lubrication


Explanation

Boundary lubrication predominates at high loads and low speeds, such as the initiation of motion. It is mediated primarily by lubricin (PRG4) attached to the articular surface.

Question 171

Topic: Physiology & Rehabilitation

Articular chondrocytes primarily rely on which of the following metabolic pathways for energy production?

. Oxidative phosphorylation
. Aerobic glycolysis
. Anaerobic glycolysis
. Beta-oxidation of fatty acids
. Gluconeogenesis

Correct Answer & Explanation

. Oxidative phosphorylation


Explanation

Articular cartilage is avascular and operates in a hypoxic environment. Consequently, chondrocytes rely predominantly on anaerobic glycolysis for ATP production, rather than oxygen-dependent pathways like oxidative phosphorylation.

Question 172

Topic: Physiology & Rehabilitation

Mature articular chondrocytes reside in an avascular environment and must generate cellular energy under characteristically hypoxic conditions. They derive the vast majority of their ATP through which of the following metabolic pathways?

. Oxidative phosphorylation
. Anaerobic glycolysis
. Fatty acid beta-oxidation
. The pentose phosphate pathway
. Ketone body utilization

Correct Answer & Explanation

. Oxidative phosphorylation


Explanation

Because articular cartilage is totally avascular, mature chondrocytes live in a profoundly hypoxic environment. They rely almost entirely on anaerobic glycolysis for ATP production, which results in a high baseline production of lactic acid.

Question 173

Topic: Physiology & Rehabilitation

Biomechanical analysis of normal human gait reveals significant joint reaction forces. During the single-limb stance phase, the hip joint reaction force is approximately what multiple of total body weight?

. 1 time body weight
. 2.5 to 3 times body weight
. 5 to 6 times body weight
. 8 to 10 times body weight
. 0.5 times body weight

Correct Answer & Explanation

. 1 time body weight


Explanation

During the single-limb stance phase of normal gait, the hip joint reaction force reaches approximately 2.5 to 3 times body weight. This force is a vector sum of the body weight and the large counteracting force generated by the abductor musculature.

Question 174

Topic: Physiology & Rehabilitation

Which type of muscle contraction generates the highest maximum tension?

. Concentric isotonic
. Eccentric
. Isometric
. Isokinetic
. Plyometric

Correct Answer & Explanation

. Concentric isotonic


Explanation

Eccentric contractions, where the muscle lengthens under tension, can generate greater maximal force than isometric or concentric contractions.

Question 175

Topic: Physiology & Rehabilitation

A 30-year-old weightlifter feels a tearing sensation in his anterior axilla while performing a heavy bench press. Examination reveals loss of the anterior axillary fold and weakness in internal rotation. Which portion of the pectoralis major is most commonly ruptured in this scenario?

. Clavicular head at the muscle origin
. Sternal head at the muscle origin
. Clavicular head at the tendinous insertion
. Sternal head at the tendinous insertion
. Musculotendinous junction of the clavicular head

Correct Answer & Explanation

. Clavicular head at the muscle origin


Explanation

Pectoralis major ruptures typically occur during eccentric contraction (like bench pressing). The sternal head at its humeral insertion is the most commonly torn portion due to its mechanical disadvantage at maximum extension.

Question 176

Topic: Physiology & Rehabilitation

A patient with advanced unilateral hip osteoarthritis is instructed to use a cane. To maximally reduce the joint reaction force on the affected hip, the cane should be held in the contralateral hand. What is the primary biomechanical reason for this reduction?

. It shifts the center of gravity laterally over the affected hip
. It provides a force that assists the abductor muscles, decreasing the required abductor force
. It increases the lever arm of the body weight
. It transfers the body weight entirely to the ipsilateral upper extremity
. It limits hip flexion during the stance phase of gait

Correct Answer & Explanation

. It shifts the center of gravity laterally over the affected hip


Explanation

Holding a cane in the contralateral hand provides an upward force at a long lever arm from the affected hip. This counter-torque dramatically reduces the amount of force the ipsilateral abductor muscles must generate, thereby decreasing the total joint reaction force.

Question 177

Topic: Physiology & Rehabilitation

When advising a patient with severe left hip osteoarthritis on the use of a single-point cane, you instruct them to hold the cane in their right hand. What is the primary biomechanical rationale for this instruction?

. It shifts the center of gravity laterally over the affected hip.
. It eliminates the need for gluteus medius contraction on the affected side.
. It provides a counter-moment that decreases the required force of the left abductor muscles, reducing the joint reaction force.
. It increases the lever arm of the body weight, effectively unloading the medial compartment of the knee.
. It restricts hip external rotation during the stance phase of gait.

Correct Answer & Explanation

. It shifts the center of gravity laterally over the affected hip.


Explanation

Using a cane in the contralateral hand provides a long lever arm that assists the ipsilateral hip abductors in maintaining a level pelvis. This significantly reduces the force the abductor muscles must generate, thereby profoundly decreasing the compressive joint reaction force across the hip.

Question 178

Topic: Physiology & Rehabilitation

A 70-year-old man with a known history of severe cervical stenosis is involved in a rear-end motor vehicle collision, resulting in a hyperextension injury. He presents to the ED with 1/5 motor strength in his bilateral upper extremities and 4/5 strength in his lower extremities. Proprioception and perianal sensation are intact. What is the most likely diagnosis?

. Anterior cord syndrome
. Brown-Sequard syndrome
. Central cord syndrome
. Posterior cord syndrome
. Conus medullaris syndrome

Correct Answer & Explanation

. Anterior cord syndrome


Explanation

Central cord syndrome typically occurs after hyperextension injuries in older patients with pre-existing cervical spondylosis. The classic presentation involves disproportionately greater motor weakness in the upper extremities compared to the lower extremities.

Question 179

Topic: Physiology & Rehabilitation

A 35-year-old male bodybuilder feels a sudden pop in his anterior axilla while performing a heavy bench press. He presents with ecchymosis, swelling, and a loss of the anterior axillary fold. MRI confirms a complete rupture of the pectoralis major tendon. Where does this rupture most commonly occur?

. Musculotendinous junction
. Clavicular head muscle belly
. Sternal head insertion onto the humerus
. Clavicular head insertion onto the humerus
. Origin at the sternum

Correct Answer & Explanation

. Musculotendinous junction


Explanation

Pectoralis major ruptures most frequently occur at the sternal head tendon insertion onto the proximal humerus during maximal eccentric contraction. Surgical repair yields the best functional outcomes for active individuals.

Question 180

Topic: Physiology & Rehabilitation

A 28-year-old competitive weightlifter experiences a tearing sensation in his anterior chest wall during a heavy bench press. Examination reveals loss of the anterior axillary fold and weakness in internal rotation. In a typical pectoralis major rupture, which head of the muscle tears most commonly?

. Clavicular head
. Sternal head
. Costal head
. Abdominal head
. Coracoid head

Correct Answer & Explanation

. Clavicular head


Explanation

Pectoralis major ruptures typically occur during eccentric contraction (e.g., bench press). The sternal (sternocostal) head is most frequently injured, often avulsing from its insertion on the proximal humerus.